银杏内酯B mPEG-PLA聚合物胶束的制备和体外性质  

Preparation and in vitro characterization of ginkgolide B-loaded mPEG-PLA polymeric micelles

作　　者：宋力[1] 何盛江 张现涛 

机构地区：[1]中国药科大学药剂学教研室,南京210009 [2]广东省中药研究所,广州510520

出　　处：《中国药科大学学报》2014年第6期681-683,共3页Journal of China Pharmaceutical University

基　　金：中央高校基本科研业务费专项基金资助项目(No.JKQ2011020);广东省自然科学基金资助项目(No.S2011010001294);广州市科技计划基金资助项目(No.2012J4300092);广州市珠江科技新星专项基金资助项目(No.2011J2200012)~~

摘　　要：以聚乙二醇单甲醚-聚丙交酯嵌段共聚物(m PEG-PLA)(50/50)作为载体,制备银杏内酯B(GB)聚合物胶束(GB-m PEG-PLA)。采用乳化-溶剂挥发制备GB-m PEG-PLA溶液,再冷冻干燥保存,并对制得的GB-m PEG-PLA的载药量、包封率、粒径与分布和胶束形态等进行表征,采用透析法考察GB-m PEG-PLA的体外释放。所制得的GB-m PEG-PLA载药量为7.5%,包封率为82.2%,平均粒径为74.5 nm;扫描电镜显示胶束为类球形;GB-m PEG-PLA释放曲线显示其具有一定的缓释作用。研究结果表明,m PEG-PLA胶束是一种极具应用前景的纳米给药系统。Ginkgolide B-loaded m PEG-PLA polymeric micelles（ GB-m PEG-PLA） was prepared by emulsification- solvent diffusion method. The drug loading,encapsulation efficiency,average particle size and size distribution of GB-m PEG-PLA were evaluated. Moreover, the in vitro release characteristics of GB-m PEG-PLA were investigated by dialysis. The average particle size of GB-mPEG-PLA was 74. 5 nm,the drug loading and encapsulation efficiency were 7. 5% and 82. 2%, respectively. SEM image showed GB-m PEG-PLA was spherical in shape. In addition,the release profile of ginkgolide B from GB-m PEG-PLA exhibited an extended-release pattern.Therefore,GB-m PEG-PLA can be a promising nano-sized drug delivery system in the future.

关 键 词：银杏内酯B 聚乙二醇单甲醚-聚丙交酯嵌段共聚物 胶束 缓释 

分 类 号：R283.6[医药卫生—中药学]