神经营养因子联合治疗促进脊髓轴索再生的研究现状  

Research Status of the Combined Treatment of Neurotrophic Factors for Promoting the Regeneration Spinal Cord Axon

作　　者：张水印[1] 顾兵[1] 李华南[2] 张国福[2] 

机构地区：[1]江西科技师范大学生命科学学院,江西南昌330013 [2]江西中医药大学附属医院脊柱外科,江西南昌330006

出　　处：《江西科技师范大学学报》2014年第6期1-6,共6页Journal of Jiangxi Science & Technology Normal University

基　　金：国家自然科学基金资助项目(30960448);江西省自然科学基金项目(20142BAB205023);江西省教育厅科技项目(GJJ12584)

摘　　要：神经营养因子(neurotrophic factors,NTFs)在急性脊髓损伤(spinal cord injury,SCI)后神经细胞的生长发育、保护和修复的过程中发挥重要作用。然而,单一的治疗尚不足以激活神经元内源性的再生程序;其次,再生抑制因子限制了NTFs对SCI后结构和功能恢复。因此,越来越多的学者选择以联合的方式探索NTFs对再生的促进作用。本文归纳了NTFs以联合的方式治疗轴索再生的基本原理和最新进展,旨在为联合治疗的进一步研究提供科学指导。neurotrophic factors（NTFs） play an important role in the nerve cell growth, protection and repair processes after acute spinal cord injury（SCI）. However, a single treatment is still not enough to activate the regeneration procedures of endogenous neurons. Secondly, regeneration inhibitory factor limits the NTFs on the recovery of structure and function after SCI. Therefore, more and more scholars choose combinatorial approaches to explore the promoting effect of NTFs on regeneration. This paper summarizes the basic principle and the latest development of NTFs in combinatorial approaches to promote axonal regeneration, in order to provide scientific guidance for the further study of combination therapy.

关 键 词：神经营养因子 脊髓损伤 联合治疗 轴索再生 

分 类 号：R965.2[医药卫生—药理学] R818.021[医药卫生—药学]