诱导多能干细胞及其移植治疗脊髓损伤的研究现状  

Induced Pluripotent Stem Cells and Their Transplantation for Spinal Cord Injury:Current Status

作　　者：张思[1] 顾兵[1] 李华南[2] 张国福[2] 张水印[1] 闵友江[2] 

机构地区：[1]江西科技师范大学生命科学学院 [2]江西中医药大学附属医院

出　　处：《神经药理学报》2013年第3期57-64,共8页Acta Neuropharmacologica

基　　金：国家自然科学基金项目(No.30960448);江西省自然科学基金项目(No.20142BAB205023);江西省教育厅科技项目(No.GJJ12584;No.GJJ14603)

摘　　要：脊髓损伤(spinal cord injury,SCI)通常是指脊髓(包含神经根)的急性创伤。一旦发生就会造成不同程度的运动及感觉功能的丧失。目前认为传统的干细胞移植尚不能完全修复SCI。诱导多能干细胞(induced pluripotent stem cells,i PSCs)兼具干细胞的多种优点,因而在细胞替代性治疗及其机制研究、新药筛选方面具有巨大的潜在价值。本文通过介绍i PSCs生物学特性及其技术现状,综述i PSCs移植治疗SCI的研究现状以及面临困境,指出应用于临床尚需解决的问题。Spinal cord injury （SCI） usually refers to the acute trauma of spinal cord （including nerve root）. The event will result in the loss of motor and sensory functions in different degrees. It is believed that currently traditional stem cell transplantation is unable to completely repair SCI. Induced pluripotent stem cells （iPSCs） with many advantages of stem cells have advance potential value in the study of cell replacement therapy, its mechanism and new drug screening. By introducing the biological characteristics of iPSCs and current status of the technology, and detailed summarizing the research status of iPSCs transplantation in SCI and its facing predicaments, this paper points out the problems need to be solved before the clinical application.

关 键 词：脊髓损伤 诱导多能干细胞 细胞移植 功能神经元 

分 类 号：R331[医药卫生—人体生理学] R965.1[医药卫生—基础医学]