胆维丁乳对糖尿病性骨质疏松症患者骨代谢指标影响的研究  

Effect of cholecalciferol cholesterol emulsion on the index of bone metabolism in diabetic patients with osteoporosis

作　　者：郑旭磊[1] 刘志文[1] 盛宏光[1] 毛旭东[1] 那日苏[1] 

机构地区：[1]上海市徐汇区中心医院内分泌科,上海200231

出　　处：《上海医药》2015年第3期44-45,48,共3页Shanghai Medical & Pharmaceutical Journal

基　　金：徐汇区中心医院科研基金(2012XH CH08)

摘　　要：目的:观察糖尿病性骨质疏松症患者应用胆维丁乳治疗后骨密度(BMD)和有关骨代谢生化指标的变化。方法:对50例糖尿病性骨质疏松症患者应用胆维丁乳治疗6个月,对比治疗前后髋部BMD、血清钙(Ca)、磷(P)、血清肌酐(Cr)、碱性磷酸酶(AKP)、25-羟维生素D2、25-羟维生素D3、25-羟维生素D2+D3、甲状旁腺素(PTH)、血清骨钙素(BGLAP)、降钙素(CT)、空腹血糖、空腹胰岛素及空腹C肽的变化。结果:研究显示,服用胆维丁乳能够明显改善患者的临床症状,有效率为90.6%;治疗6个月后,血钙浓度、AKP、25-羟维生素D3及25-羟维生素D2+D3均有所升高,差异具统计学意义(均P<0.05)。结论:应用胆维丁乳可以有效地改善有关骨代谢的生化指标。Objective： To investigate the change of biochemical indexes such as bone mineral density （BMD） and bone metabolism in 50 cases of diabetic patients with osteoporosis, who were treated with a cholecalciferol cholesterol emulsion for 6 months. Methods： The levels of hip BMD, serum calcium, phosphorus, creatinine, AKP, 25-hydroxy vitamin D2, 25-hydroxy vitamin D3, 25-hydroxy vitamin D2＋D3, parathyroid hormone （PTH）, osteocalcin, calcitonin （CT）, fasting blood-glucose （FBG）, fasting insulin and C-P were compared before treatment and 6 months after. Results： Cholecalciferol cholesterol emulsion could significantly improve the clinical symptoms with the effective rate 90.6%. The levels of calcium, AKP, 25-hydroxy vitamin D3 and 25-hydroxy vitamin D2＋D3 were all elevated after 6 months treatment and their differences were statistically significant （average P〈0.05）. Conclusion： Cholecalciferol cholesterol emulsion can effectively improve the biochemical indexes related to bone metabolism.

关 键 词：胆维丁乳 糖尿病性骨质疏松症 骨密度骨 代谢 

分 类 号：R587.2[医药卫生—内分泌] R977.24[医药卫生—内科学]