I_2/离子液体作为可回收均相催化剂在微波条件下高效制备全乙酰糖(英文)  

I_2/ionic liquid as a highly efficient catalyst for per-O-acetylation of sugar under microwave irradiation

作　　者：熊兴泉[1] 易超[1] 韩骞[1] 石霖[1] 李四中[1] 

机构地区：[1]华侨大学材料科学与工程学院,福建省高校功能材料重点实验室,福建厦门361021

出　　处：《催化学报》2015年第2期237-243,共7页

基　　金：supported by the National Natural Science Foundation of China(21004024);the Natural Science Foundation of Fujian Province(2011J01046);the Program for New Century Excellent Talents in University of Fujian Province(2012FJ-NCET-ZR03);the Promotion Program for Young and Middle-Aged Teachers in Science and Technology Research of Huaqiao University(ZQN-YX103);the Special Foundation for Young Scientists of Fujian Province(2011J05131)~~

摘　　要：以可回收的I2/PEG400型离子液体(I2/IL400)为催化体系,发展了一种高效、实用的合成全乙酰糖衍生物的方法.结果表明,以糖与乙酸酐为原料,在微波辐射、无溶剂条件以及I2/IL400体系中,数分钟之内可以非常高的产率(90%–99%)和数十毫摩尔规模(50.0 mmol)制备出全乙酰糖.通过简单的甲苯萃取,可以从I2/IL400体系中分离出全乙酰糖,I2/IL400体系可循环使用6次,且产率均在90%以上.当反应规模扩大到50.0 mmol时,该体系依然能高效快速地催化糖的全乙酰化,并且可以循环使用5次,产率依然维持在90%左右.A practical and highly efficient approach was developed to synthesize peracetylated sugar derivatives using a recyclable iodine/PEG_400-based ionic liquid catalyst（I_2/IL].The peracetylated sugars were readily obtained in a few minutes in excellent yields（90%-99%,13 examples]on a multi-gram scale（50.0 mmol） by the reaction of sugar and acetic anhydride under microwave irradiation in the absence of a volatile organic solvent.The desired product was easily obtained by simple extraction with toluene from the reaction mixture,and I_2/ILs can be readily recovered and reused at least six times without obvious loss in the yield.When the scale of the per-O-acetylation reaction was increased to 50.0 mmol,the desired product was still obtained in 90%yield after five recycles.

关 键 词：全乙酰糖 碘 离子液体 微波辐射 

分 类 号：O629.1[理学—有机化学]