丙氨酸转移酶初筛对献血合格率的影响  

Analysis of ALT screening in blood donations impact on pass rate

作　　者：刘桂晔 许璐[2] 陈正利[2] 

机构地区：[1]南阳市中心血站检验科,河南南阳473000 [2]河南省疾病预防控制中心信息中心,河南郑州450016

出　　处：《西部医学》2015年第2期291-292,共2页Medical Journal of West China

基　　金：河南省疾病预防控制科研项目(YWZY201367)

摘　　要：目的探讨进行丙氨酸转移酶(ALT)检测对献血合格率的影响,分析开展ALT筛查对提高用血安全的意义。方法随机将2011年5387份血液标本作为观察组,随机抽2010年的4189份血液作为对照组,对照组未进行ALT初筛,观察组进行ALT初筛,比较两组血液废弃率以及第二次筛查的ALT不合格率。结果观察组血液报废率为3.1%(167/5387份),对照组为5.71%(239/4189份),观察组的血液报废率明显低于对照组,差异有统计学意义(P<0.05)。观察组初筛后ALT不合格率为2.7%,经复检ALT不合格率为1.2%,对照组ALT复检不合格率为3.8%,观察组复检的ALT不合格率明显低于对照组,差异有统计学意义(P<0.05)。结论在核酸检测等新技术广泛应用于血液筛查之前,对献血者献血前进行血液ALT初筛检测可有效降低ALT报废率,提高献血合格率,保障用血的安全性。Objective To investigate the affects of alanine aminotransferase（ALT）detection on pass rate of blood donation,p reliminary analysis the significance of ALT screening at this stage to improve blood using safety.Methods5387 samples of blood were selected as observation group and controlled with 4189 samples of blood.The control group did not perform ALT screening,but the observation group did.The scrap rate was observed.Results The blood discarded rate of observation group and the control group were 3.1% and 5.71%（P〈0.05）.The blood ALT screening failure rate of observation group and the control group were 1.2% and 3.8%（P〈0.05）.Conclusion Before nucleic acid detection and other new technologies are widely used in blood screening,Blood ALT screening test can effectively reduce scrap rates,improve blood passing rate and guarantee the safety of blood.

关 键 词：ALT初筛 献血 合格率 血液安全 

分 类 号：R457.1[医药卫生—治疗学]