从“初病湿热在经,久则瘀热入络”探讨肝纤维化的病因病机  

Discussion on the etiology and pathogenesis of hepatic fibrosis from the theory of ‘dampness-heat in initial stage of diseases is at meridians, and stagnant heat invaded into collaterals'

作　　者：鲁玉辉[1] 徐文洋[1] 王心蕊[1] 郑春素[1] 高展翔[1] 

机构地区：[1]福建中医药大学中医学院,福州350122

出　　处：《中华中医药杂志》2015年第2期349-353,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金资助项目(No.81173180);福建省自然科学基金资助项目(No.2011J01216)~~

摘　　要：文章从叶天士"其初在气在经,其久"入络入血"以及"初病湿热在经,久则瘀热入络"等观点探讨肝纤维化过程中"湿热"和"瘀热"等因素在各个阶段所发挥的不同作用,对"湿热""湿热化瘀""瘀热入络"等病因病机以及"久病入络"和"肝络"的内涵做相应阐述,探讨其由"气分"到"血分"最终形成"络病"的演变规律。提出肝纤维化的发展中"湿热"为始动因素,久则"化瘀入络"的观点,在肝纤维的防治中应重视"湿热"及"瘀热入络"在发病中的关键作用,及时逆转、阻断或延缓肝纤维化进程。The roles of dampness-heat and stagnant heat in different stages of hepatic fibrosis were explored based on the theory of ‘disease in qi phase at early stage and invading into blood phase＇ and the points of ‘dampness-heat in initial stage of diseases is at meridians, and stagnant heat invaded into collaterals＇. The etiology and pathogenesis of dampness-heat, dampnessheat transforming blood stasis and stagnant heat invading into collaterals were explored in this article. Meanwhile, the concepts of prolonged disease invading into collaterals and liver collaterals were illustrated in the paper. The evolvement rule from qi phase to blood phase eventually into collaterals was analyzed. A new point that dampness-heat was the initiating factor in the process of hepatic fibrosis and invaded into collaterals for long time was put forward. In the prevention and treatment of liver fibrosis, dampness-heat and stagnant heat should be paid attention. And the progress of hepatic fibrosis should be reversed, blocked or delayed in time.

关 键 词：肝纤维化 湿热 瘀热 经 络 病因病机 

分 类 号：R259[医药卫生—中西医结合]