藤梨根化学成分的研究  

Chemical constituents of the root of Actinidia chinensis Planch.

作　　者：何国浓 胡秀敏 王辉[3] 樊莉 王邦才 

机构地区：[1]宁波市中医院,宁波315010 [2]北京市石景山区食品药品安全监控中心,北京100043 [3]浙江中医药大学,杭州310053

出　　处：《中华中医药杂志》2015年第2期498-500,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：浙江省中医药科技计划(No.2013ZA115)~~

摘　　要：目的:研究藤梨根Actinidia chinensis Planch.的化学成分。方法:利用硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法、半制备高效液相色谱等方法分离纯化;通过核磁共振谱、质谱等光谱数据鉴定化合物结构。结果:分离得到10个化合物,分别鉴定为β-谷甾醇(Ⅰ)、熊果酸(Ⅱ)、齐墩果酸(Ⅲ)、胡萝卜苷(Ⅳ)、香豆酸(Ⅴ)、对羟基苯甲酸(Ⅵ)、3-吲哚甲酸(Ⅶ)、2α,3α,24-三羟基乌苏烷-12-烯-28酸(Ⅷ)、2α,3α,19α,24-四羟基乌苏烷-12-烯-28-酸(Ⅸ)、2α,3α,24-三羟基齐墩果烷-12-烯-28酸(Ⅹ)。结论:化合物Ⅴ、Ⅵ、Ⅶ为首次从本植物中分离得到。Objective： To investigate the chemical constituents of the root of Actinidia chinensis Planch.. Methods： The constituents were isolated by silica gel chromatography, Sephadex LH-20 gel column chromatography, semi-preparative high performance liquid chromatography and their structures were elucidated by chemical properties and spectral analysis. Results： Ten compounds were isolated and their structures were identified to be β-sitosterol（Ⅰ）; ursolic acid（Ⅱ）; oleanolic acid（Ⅲ）; daucosterol（Ⅳ）; coumalic acid（Ⅴ）; p-hydroxybenzoic acid（Ⅵ）; indole-3-carboxylic acid（Ⅶ）; 2α,3α,24-trihydroxyurs-12-en-28-oic acid（Ⅷ）; 2α,3α,19α,24-tetrahydroxyurs-12-en-28-oic acid（Ⅸ）; 2α,3α,24-trihydroxyolean-12-en-28-oic acid（Ⅹ）. Conclusion： Compounds Ⅴ, Ⅵ, Ⅶ were obtained from this plant for the first time.

关 键 词：藤梨根 化学成分 分离鉴定 

分 类 号：R284[医药卫生—中药学]