中药莪术对肿瘤相关信号通路影响研究进展  

Effect of Curcuma on Tumor-associated Signaling Pathway

作　　者：李宝石[1] 夏宁俊[2] 朱超林[3] 

机构地区：[1]南京军区南京总医院,江苏南京210002 [2]南京中医药大学,江苏南京210046 [3]江苏省中医院,江苏南京210029

出　　处：《辽宁中医药大学学报》2015年第2期188-191,共4页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：莪术是常用的抗肿瘤中药,含莪术油(主要为莪术醇和莪术酮)、β-榄香烯、姜黄素等多种活性成分,现代药理研究表明这些成分均能调节PI3K/Akt、MAPK、VEGF、JAK-STAT等多种关键信号通路,从而发挥抑制肿瘤细胞增殖、促进细胞凋亡等作用。该文就近年来有关文献进行回顾,对此进展作一综述。Curcuma is a commonly-used anti-tumor Chinese medicine which contains Curcuma oil（mainly curcumol and curcuma ketone）,β-elemene,curcumin and other active ingredients. Modern pharmacological studies have shown that the ingredients of Curcuma can regulate PI3K/Akt,MAPK,VEGF,JAK-STAT and other key signaling pathways and play the anti-tumor action by inhibiting of tumor cell proliferation and promoting of apoptosis. In this article,we provide an overview of recent literatures about this.

关 键 词：莪术 恶性肿瘤 信号通路 研究进展 

分 类 号：R273[医药卫生—中西医结合]