热休克蛋白47与PⅠCP在慢性心力衰竭患者中的相关性  

Correlation between heat shock protein 47 and pro-collagen type I C-terminal peptide in patients with chronic heart failure

作　　者：田倪妮 魏玲[1] 李宏键[3] 陈黔[1] 倪茂娥 马玲[1] 林梦娇 

机构地区：[1]成都军区昆明总医院地方干部病房,云南昆明650032 [2]昆明医科大学研究生部,云南昆明650032 [3]云南省第一人民医院骨科,云南昆明650034 [4]云南省开远市人民医院儿科,云南开远661000

出　　处：《心脏杂志》2015年第1期45-47,共3页Chinese Heart Journal

摘　　要：目的:慢性心力衰竭(CHF)是一种慢性的,逐渐进展的临床综合征。研究热休克蛋白47(HSP47)与血清Ⅰ型胶原羧基端肽(PⅠCP)在CHF不同心功能分级中的表达及其相关性。方法:将60名患者分为心功能Ⅰ级、心功能Ⅱ级、心功能Ⅲ级,采用ELISA测定患者血清中的HSP47的含量与PⅠCP的含量,并研究两者与CHF的相关性。结果:与心功能1级组比较,心功能Ⅱ级组PⅠCP含量显著增高(P<0.01),且心功能Ⅲ级组较心功能Ⅱ级组PⅠCP含量显著增高(P<0.01),且血清HSP47含量与PⅠCP含量呈正相关。结论:CHF患者存在心肌纤维化及左心室扩大,两者呈正相关关系,提示CHF患者存在心室结构重构,心肌纤维化在心室重构中起重要作用。CHF患者HSP47和PⅠCP显著升高,且呈显著正相关。AIM： To study the correlation between heat shock protein 47 and pro-collagen type I C-terminal peptide （PICP） in patients with different classifications of chronic heart failure （CHF）. METHODS： Sixty patients were equally divided into three groups： NYHA I group, NYHA II group, and NYHA III group （n = 20 in each group）. Expressions of HSP47 and PICP in serum were measured by enzyme-linked immunosorbent assay （ELISA）. RESULTS： Serum concentration of PICP in the NYHA II group was significantly higher than in the NYHA I group and the concentration of serum PICP in NYHA III group was significantly higher than in the NYHA II group （ both P 〈 0.05 ）. A positive correlation was found between expression of HSP47 and PICP. CONCLUSION： Myocardial fibrosis and left ventricular diameter are positively correlated, suggesting that myocardial fibrosis plays an important role in ventricular remodeling. HSP47 and PICP in blood-serum have a significantly positive correlation in patients with CHF.

关 键 词：热休克蛋白47 心力衰竭 慢性 心肌纤维化 心室重构 

分 类 号：R541.6[医药卫生—心血管疾病]