川崎病患儿血清脂联素水平的变化  

Serum adiponectin levels in children with Kawasaki disease

作　　者：黄秒[1] 董国庆[1] 蒋红英[1] 张纪泳[1] 石小娟[1] 

机构地区：[1]南方医科大学附属深圳妇幼保健院儿科,广东深圳518028

出　　处：《中国当代儿科杂志》2015年第1期35-39,共5页Chinese Journal of Contemporary Pediatrics

基　　金：深圳市科技计划项目(201203099)

摘　　要：目的探讨川崎病(Kawasaki disease,KD)患儿血清脂联素的变化及意义。方法选取KD患儿45例,其中冠状动脉损伤(CAL)患儿18例,未合并CAL患儿27例;另选取健康儿童20例作为对照组。采用ELISA法检测血清脂联素水平,全自动生化测定仪检测血脂四项,包括甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)。结果合并CAL与未合并CAL组急性期、亚急性期、恢复期血清脂联素水平均低于正常对照组(P<0.01);急性期与亚急性期其水平均低于恢复期(P<0.01)。在急性期与恢复期,CAL组血清脂联素水平显著高于未合并CAL组(P<0.05)。合并CAL与未合并CAL组血清TC、HDL、LDL均较正常对照组降低(P<0.05)。KD患儿血清脂联素水平与TC、TG、CRP水平及CAL的发生呈明显正相关,r分别为0.31、0.30、0.34、0.35,均P<0.05。结论 KD患儿存在血脂紊乱及低脂联素水平;血清脂联素水平降低可能是全身炎症反应的结果;血清脂联素增加与CAL的发生关系密切。Objective To explore the change in serum adiponectin levels and its signiifcance in children with Kawasaki disease （KD）. Methods Forty-ifve KD patients were enrolled in this study, including 18 with coronary artery lesions （CAL group） and 27 without coronary artery lesions （NCAL group）. Twenty healthy children were recruited to the control group. Enzyme-linked immunosorbent assay was used to measure serum adiponectin levels, and an automatic biochemical analyzer was used to measure the levels of triglyceride （TG）, total cholesterol （TC）, low-density lipoprotein cholesterol （LDL-C）, and high-density lipoprotein cholesterol （HDL-C）. Results The serum adiponectin levels in the CAL and NCAL groups were signiifcantly lower than in the control group during the acute phase, subacute phase, and recovery phase （P〈0.01）, with lower levels observed during the acute phase and subacute phase （P〈0.01）. Compared with the NCAL group, the CAL group had signiifcantly higher serum levels of adiponectin during the acute phase and recovery phase （P〈0.05）. The levels of TC, HDL, and LDL in the NCAL and CAL groups were significantly lower than in the control group （P〈0.05）. The levels of serum adiponectin in KD patients were positively correlated with the levels of TC, TG, and C-reactive protein and the occurrence of CAL （r=0.31, 0.30, 0.34, and 0.35, respectively;P〈0.05）. Conclusions Children with KD have metabolic disorders of blood lipids and reduced serum adiponectin levels. Reduced serum adiponectin levels may be the result of systemic inlfammation, while increased adiponectin levels may be closely associated with the occurrence of CAL.

关 键 词：川崎病 脂联素 冠状动脉损伤 血脂 儿童 

分 类 号：R725.4[医药卫生—儿科]