雌激素受体α基因rs2234693位点多态性与前列腺癌易感性的meta分析  

A meta-analysis of ESRα rs2234693 polymorphism associated with prostate cancer risk

作　　者：马英东[1] 王阿妮[2] 钟韶萍 金莉子[3] 

机构地区：[1]中山大学附属第五医院介入科,广东珠海519000 [2]中山大学附属第五医院心内科,广东珠海519000 [3]中山大学附属第五医院冠心病重症监护室,广东珠海519000

出　　处：《中国病理生理杂志》2015年第1期104-108,共5页Chinese Journal of Pathophysiology

基　　金：珠海市科技计划项目(No.2012D0401990002)

摘　　要：目的:探讨雌激素受体α(ESRα)基因rs2234693位点多态性与前列腺癌易感性的关系。方法:通过计算机检索Pub Med、CNKI和万方数据库,根据纳入与排除标准筛选相关的病例对照研究,检索时限至2014年4月。在提取有效资料后,应用Stata 10.1分析软件对各项研究进行异质性检验,在随机效应模型下计算合并优势比及其95%可信区间。结果:该Meta分析共纳入20项研究,累计前列腺癌组4 623例,对照组9 850例。ESRαrs2234693位点多态性在总体人群中与前列腺癌易感性明显相关(P<0.05),通过种族的亚组分析发现ESRαrs2234693位点多态性与前列腺癌易感性在欧洲人群中具有相关性(P<0.05),然而在亚洲和非洲人群中无明显关联性(均P>0.05)。结论:ESRα基因rs2234693位点态性与前列腺癌易感性相关,即rs2234693的CC基因型可增加人群患前列腺癌的风险,尤其是欧洲人群。AIM：To investigate the pooled association between estrogen receptor α（ ESRα） rs2234693 poly-morphism and prostate cancer risk .METHODS：A systematic literature search was performed to identify the related stud-ies （up to April 2014） in several online databases including PubMed , the CNKI and Wanfang online libraries .Odds ratios with 95%confidence intervals were used to calculate the strength of association in the random effect model .RESULTS：A total of 20 studies including 4 623 cases and 9 850 controls were enrolled in the final meta-analysis.The results indicated that ESRαrs2234693 polymorphism was significantly associated with prostate cancer risk （P〈0.05） in a dominant genetic model.In the subgroup analysis by ethnicity , there were significant associations between ESRαrs2234693 polymorphism and prostate cancer risk in Caucasians （ P〈0.05 ） , but not in Asians and Africans （ both P〉0.05 ） .CONCLUSION：This meta-analysis suggests that ESRαrs2234693 polymorphism is significantly associated with prostate cancer risk , espe-cially in Caucasians .

关 键 词：雌激素受体Α 基因多态性 前列腺肿瘤 META分析 

分 类 号：R195.1[医药卫生—卫生统计学] R4[医药卫生—卫生事业管理]