普瑞巴林对腰椎间盘突出症术后疼痛的影响  

Effects of pregabalin on postoperative pain in lumbar disc herniation

作　　者：王宏家[1] 钟声宇[2] 李德江[1] 李广程[1] 

机构地区：[1]吉化集团公司总医院骨科,吉林吉林132021 [2]吉林市中心医院骨科,吉林吉林132021

出　　处：《中国新药与临床杂志》2015年第1期48-51,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的观察普瑞巴林用于腰椎间盘突出症术后镇痛的效果及安全性。方法择期行腰椎间盘突出症手术的患者72例,随机分为三组,每组24例。普瑞巴林组和塞来昔布组患者分别于麻醉前2 h口服普瑞巴林300 mg或塞来昔布400 mg,术后12 h开始口服普瑞巴林150 mg或塞来昔布200 mg,q12h;对照组在相应的时点给予维生素C。三组其余麻醉及给药方式相同,均以曲马多辅助镇痛。记录术后2、6、12、24、48 h患者的视觉模拟量表评分(VAS)及术后48 h内曲马多用量、不良反应发生率及患者满意率。结果术后各时间点普瑞巴林组和塞来昔布组静息痛和活动痛VAS均低于对照组(P<0.05),普瑞巴林组活动痛VAS低于塞来昔布组(P<0.05),静息痛VAS与塞来昔布组相似(P>0.05)。普瑞巴林组和塞来昔布组曲马多人均用量均低于对照组(P<0.05),两组间无显著差异(P>0.05)。术后48 h,对照组不良反应发生率33%,高于普瑞巴林组和塞来昔布组(12%和25%,P<0.05),均未见严重不良反应发生;普瑞巴林组满意率79%,高于塞来昔布组和对照组(67%和25%,P<0.05)。结论腰椎间盘突出症围手术期应用普瑞巴林镇痛效果良好且安全,患者满意率高。AIM To observe the effects and safety of pregabalin on postoperative pain of patients with lumbar spinal stenosis. METHODS Seventy- two patients undergoing lumbar disc herniation surgery were randomly divided into three groups, each group of 24 patients. The patients in the pregabalin group and celecoxib group were administered with pregabalin 400 mg or celecoxib 300 mg two hours before anesthesia, and pregabalin 200 mg or celecoxib 150 mg, ql2h beginning at 12 h after operation. The patients in the control group were given vitamin C at the corresponding time point. The remaining anesthesia and administered drugs were the same among three groups, and all patients with tramadol auxiliary analgesia. The visual analogue score （VAS） were recorded at 2, 6, 12, 24 and 48 h after the operation. The tramadol dosage, adverse reaction and patient satisfaction during 48 pain VAS in the pregabalin h after the operation were observed. RESULTS The rest pain VAS and activity group and celecoxib group were lower than those in the control group at each postoperative time point （P 〈 0.05）. The activity pain VAS in the pregabalin group was lower compared with that in the celecoxib group （P 〈 0.05） and rest pain VAS score showed no significant difference （P 〉 0.05）. The tramadol dosage per patient in the pregabalin group and celecoxib group were lower than that in the control group （P 〈 0.05）, and no significant difference between pregabalin group and celecoxib group （P 〉 0.05）. The adverse reaction rate was 33% in the control group, higher than those in the pregabalin group and celecoxib group （12% and 25%, P 〈 0.05）. No serious adverse reaction occurred. The satisfaction rate of the pregabalin group was 79%, higher than those of the celecoxib group and control group （67% and 25%, P 〈 0.05）. CONCLUSION Pregabalin is effective and safety in postoperative analgesia for lumbar spinal stenosis patients and with high patient satisfaction rate.

关 键 词：椎间盘移位 椎间盘切除术 镇痛 普瑞巴林 塞来昔布 

分 类 号：R971[医药卫生—药品]