泮托拉唑钠肠溶微丸胶囊与盐酸伊托必利治疗功能性消化不良的临床效果观察  

Treating functional dyspepsia with pantoprazole Sodium Enteric-coated Capsules combined with itopride hydrochloride:a clinical observation

作　　者：张晓海[1] 张洪涛[1] 厉朝喜[2] 

机构地区：[1]浙江省皮肤病防治研究所内科,浙江德清313200 [2]浙江医院内科,浙江杭州310013

出　　处：《中国中西医结合消化杂志》2015年第1期33-35,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]对比不同给药方案对功能性消化不良(FD)患者的疗效。[方法]将我院收治的149例FD患者依据用药方案差异随机分为2组,其中74例单用盐酸伊托必利治疗设为对照组,其余75例将盐酸伊托必利联合泮托拉唑钠肠溶微丸胶囊治疗设为观察组,对比2组4周后的疗效、复发率与不良反应情况。[结果]2组用药4周后总有效率为83.78%和96.00%,对照组远不及观察组效果理想(P<0.05);观察组在用药1、3、6个月后复发率分别为8.00%、17.33%、24.00%,对照组在此时间点复发率分别为9.46%、21.62%、41.89%,组间在用药6个月后复发率差异明显(P<0.05);2组均未见1例与用药相关的不良反应症状。[结论]采用泮托拉唑钠肠溶微丸胶囊联合盐酸伊托必利治疗FD,效果理想且远期观察复发率较低,患者无明显不良反应,值得临床推广。[Objective]To compare the effects of different dosage regimens on patients with functional dyspepsia （FD）. [Methods]Total 149 cases of FD patients were randomly divided into two groups based on different dosage regimens, 74 cases in control group administered with only itopride hydrochloride,75 cases in observation group with the combination of pantoprazole Sodium Enteric-coated Capsules and itopride hydroehloride. After four weeks, the therapeutic effects, recurrence rates,and side effects of both groups were observed. [Results] The total effective rates of the two groups were 83.78% and 96.00% respective- ly, the effect of the control group was far less ideal than that of observation group（P〈0.05）;recurrence rates in the observation group were 8.00%, 17.33% and 24.00% at 1, 3, and 6 month after the medica- tion , while the rates were 9.46%,21.62% and 41.89% in the control group at the same time points. The difference between the two groups at 6 month was of obvious significance（P〈0.05）. No adverse event re- lated to the medication was observed in both groups. [Conclusion]Treating FD with pantoprazole Sodium Enteric-coated Capsules combined with itopride hydrochloride is of ideal effect, with low recurrence rates and no medication-related adverse events. It is worthy of clinical promotion.

关 键 词：泮托拉唑钠肠溶微丸胶囊 盐酸伊托必利 功能性消化不良 

分 类 号：R256.3[医药卫生—中医内科学]