黄芩苷与红景天胶囊对急性高原病预防作用比较  

Effect of baicalin capsules on acute mountain sickness in healthy young males at acute high altitude exposure

作　　者：段炜[1] 孙书红[1] 惠增骞[1] 高钊[1] 胡建库[1] 金峰 陈虹[3] 

机构地区：[1]武警陕西总队医院,西安710054 [2]武警西藏总队后勤部卫生处,拉萨850005 [3]武警后勤学院生药及药剂教研室,天津300162

出　　处：《武警医学》2015年第1期75-78,共4页Medical Journal of the Chinese People's Armed Police Force

基　　金：武警部队后勤部2012年科研项目(WJWSB2012-11)

摘　　要：目的探讨黄芩苷胶囊对急性高原病(acute mountain sickness,AMS)的预防作用。方法采用随机对照的研究方法,80名急进高原健康男性青年随机分为3组,黄芩苷组(n=32)、红景天组(n=24)和安慰剂组(n=24)。3组在进入高原前2 d、进入高原后连续3 d分别服用黄芩苷胶囊(0.5 g,2次/d)、红景天胶囊(0.76 g,2次/d)和安慰剂(2粒,2次/d)。检测急进高原前(海拔397 m)和急进高原后(3658 m)受试者氧饱和度、心率、收缩压、舒张压,彩色多普勒超声测量肺动脉收缩压(pulmonary artery systolic pressure,PASP)和平均肺动脉压(mean pulmonary arterial pressure,MPAP),统计急进高原后各组的AMS发病率。结果急进高原后安慰剂组、黄芩苷组和红景天组的AMS发病率分别为58.3%(14/24)、25.0%(8/32)和29.2%(7/24),与安慰剂组比较,黄芩苷组及红景天组AMS发病率明显降低,差异有统计学意义(P<0.05)。与急进高原前比较,各组受试者急进高原后心率、血压及肺动脉压均升高,氧饱和度降低(P<0.05);与安慰剂组比较,黄芩苷组血压及心率明显降低(P<0.05),红景天组急进高原后氧饱和度升高、肺动脉压降低(P<0.05)。结论黄芩苷组可能通过降低血压及心率预防AMS的发生,红景天胶囊可能通过升高氧饱和度,降低PASP、MPAP预防AMS的发生。Objective To investigate the effect of baicalin capsules for acute mountain sickness （ AMS） prevention with rapid airlift ascent to high altitude .Methods A randomized controlled trial was conducted on 80 healthy young men with baicalin capsules （0.5 g bid, n=32）, rhodiola capsules （0.76 g bid, n=24）, or placebo （n=24）, for 2 days prior to airlift ascent （397 m） and for the first 3 days at high altitude （3658 m）.AMS, oxygen saturation （SpO2）, heart rate （HR）, systolic blood pressure（SBP）, diastolic blood pressure （ DBP） , pulmonary artery systolic pressure （ PASP） and mean pulmonary arterial pressure （ MPAP） were assessed both at 397 m and 3658 m.Results After high-altitude exposure, significantly fewer participants in the baicalin capsules group （n=8, 25.0%） and rhodiola capsules group（n=7, 29.2%） developed acute mountain sickness compared with participants receiving placebo （n=14, 58.3%） （P＆lt;0.05） .HR, SBP, DBP, PASP and MPAP increased with altitude exposure （P＆lt;0.05）, and SpO2 decreased with alti-tude exposure （P＆lt;0.05）.AMS, HR, SBP and DBP with baicalin capsules was lower than those with placebo （P＆lt;0.05）; AMS, PASP, MPAP with rhodiola capsules were lower than those with placebo （P＆lt;0.05） and SpO2 was higher than that with placebo （P＆lt;0.05）.Conclusions Baicalin capsules for AMS prevention also reduce HR , SBP and DBP with rapid airlift ascent to high altitude and rhodiola capsules for AMS prevention also reduce PASP , MPAP, increase SpO2 with rapid airlift ascent to high altitude .

关 键 词：急性高原病 黄芩苷胶囊 红景天胶囊 血压 肺动脉压 

分 类 号：R594.3[医药卫生—内科学]