杂合式血液净化在急性百草枯中毒早期全身炎症反应综合征治疗作用  

The influence of hybrid renal replacement therapy(HRRT) on the Paraquat poisoning patients with systemic inflammatory response syndrome

作　　者：解德琼[1] 张臣丽[1] 唐前容 赵平[1] 敖丽娜[1] 朱磊[1] 李程[1] 胡萍[1] 

机构地区：[1]宜宾市第二人民医院肾内科,四川宜宾644000

出　　处：《临床急诊杂志》2015年第1期9-11,14,共4页Journal of Clinical Emergency

摘　　要：目的:动态观察百草枯中毒患者血浆中炎性细胞因子的变化,探讨杂合式血液净化治疗对百草枯中毒早期全身炎症反应综合征的治疗作用及机制。方法:将我科2013-01-2014-06百草枯中毒全身炎症反应综合征患者40例随机分为常规治疗组和杂合组(CVVH+HP),检测两组患者治疗前后1、3、7d的C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、IL-6及APACHEⅡ评分。结果:治疗组和对照组患者第7天各项检测指标比较差异有统计学意义(P<0.05)。结论:杂合式血液净化能改善百草枯中毒早期全身炎症反应综合征,适用于百草枯中毒的治疗。Objective：To sduty the influence of hybrid renal replacement therapy（HRRT）on the Paraquat poi- soning patients with systemic inflammatory response syndrone. Method：40 patients with paraquat poisoning show- ing SIRS were divided into normal group and HRRT group. Then the the plasma levels of CRP and TNF-α, IL-6 were detected by ELISA and APACHE Ⅱ scores were calculated on the 1 st and 3,7 th day after admission. Result： In HRRT group,Acute physiology and chronic health evaluation Ⅱ （APACHEⅡ ） scores of normal group were significantly higher than those of HRRT group at different time points after admission （all P〈0.01）. There was significant correlation of APACHE Ⅱ with each inflammatory mediator at each time point and the coefficients were similar. Conclusion： Hybrid renal replacement therapy is an effective method for the treatment of Paraquat poisoning.

关 键 词：百草枯 全身炎症反应综合征 杂合式血液净化 

分 类 号：R595[医药卫生—内科学]