2010-2013年新疆HIV亚型和耐药传播研究  

Research on HIV subtypes and drug resistance transmission in Xinjiang in 2010-2013

作　　者：董永慧[1] 王莉 何翠[3] 佐合拉·吐尔地[1] 王凤英[1] 廖玲洁[3] 关晓霞 刘伟 赵杰 邢辉[3] 

机构地区：[1]新疆疾病预防控制中心性病艾滋病预防控制中心,乌鲁木齐830002 [2]伊犁州疾病预防控制中心,新疆伊宁835000 [3]中国疾病预防控制中心性病艾滋病预防控制中心,北京100050

出　　处：《中国艾滋病性病》2015年第1期20-23,共4页Chinese Journal of Aids & STD

基　　金：国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”(2012ZX10001-002)~~

摘　　要：目的 通过对新疆艾滋病病毒（HIV）感染者的病毒基因序列分析,了解2010-2013年新疆HIV亚型和耐药传播情况。方法 采集当年新报告的16~25岁未接受抗病毒治疗的HIV-1感染者的血浆样本,提取病毒核糖核酸（RNA）,通过扩增HIV-1 pol区片段,进行测序和耐药基因变异分析。结果 4年共获得pol区序列150条,主要以CRF07_BC为主（96.7%,145/150）,共有3例出现耐药,分别针对非核苷类抑制剂（NNRTIs）和核苷类抑制剂（NRTIs）。耐药株主要出现在性传播人群中。结论 各传播途径中仍主要流行CRF07_BC,新疆HIV-1耐药传播目前处于低度传播水平,但仍需进一步加强对感染者的耐药监测和病人的治疗管理。Objective To understand HIV subtypes and drug-resistance transmission in Xinjiang in 2010-2013 through viral sequence analysis in HIV infected patients in Xinjiang. Methods Blood samples were collected from antiretroviral naive HIV infected patients aged 16 to 25 years newly reported in the current year. Viral RNA was extracted. HIV-1 pol was amplified sequenced to analyze drug resistance gene mutation. Results A total of 150 sequences of pol gene were gotten within 4 years, predominated by CRF07_BC （96.7%, 145/150）. A total of 3 cases were drug resistant to nucleoside inhibitors （NNRTIs） and nucleoside inhibitors （NRTIs）, which mainly appeared in sexually transmitted population. Conclusion CRF07_BC is still the main subtype in each route of transmission. Drug-resistance transmission of HIV-1 in Xinjiang is at a low level, but it is still needed to further strengthen drug resistance monitoring and treatment management of HIV/AIDS patients.

关 键 词：艾滋病病毒 基因序列 耐药毒株 

分 类 号：R373.9[医药卫生—病原生物学]