Synthesis of Glutathione Imprinted Polymer Particles via Controlled Living Radical Precipitation Polymerization  

作　　者：宋任远 Xiao-ling Hu Ping Guan Ji Li Li-wei Qian Qiao-li Wang 

机构地区：[1]School of Natural and Applied Science,Northwestern Polytechnical University

出　　处：《Chinese Journal of Polymer Science》2015年第3期404-415,共12页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.21174111);Graduate Starting Seed Fund of Northwestern Polytechnical University(No.Z2013145)

摘　　要：A general protocol was described for fabricating uniform molecularly imprinted polymer （MIP） particles via controlled living radical precipitation polymerization at ambient temperature. By adopting glutathione as model template, benzyl dithiocarbamate as iniferter agent, 4-vinylpyridine as monomer, and ethylene glycol dimethacrylate as cross-linker, it is demonstrated that the polymerization parameters including the iniferter concentration, monomer loading and molar ratio of cross-linker to functional monomer have profound effect on the final particle size and recognition property of the MIP particles. The batch static binding experiments were carried out to estimate the adsorption kinetics, adsorption isotherms and selective recognition of the MIP particles. The adsorption behavior followed the pseudo-second order kinetic model, revealing that the process was chemically carried out. Two adsorption isotherm models were applied to analyze equilibrium data, obtaining the best description by Langmuir isotherm model. In addition, the MIP particles also could selectively recognize glutathione over similar analogs, indicating the possibility for the separation and enrichment of the template from complicated matrices.A general protocol was described for fabricating uniform molecularly imprinted polymer （MIP） particles via controlled living radical precipitation polymerization at ambient temperature. By adopting glutathione as model template, benzyl dithiocarbamate as iniferter agent, 4-vinylpyridine as monomer, and ethylene glycol dimethacrylate as cross-linker, it is demonstrated that the polymerization parameters including the iniferter concentration, monomer loading and molar ratio of cross-linker to functional monomer have profound effect on the final particle size and recognition property of the MIP particles. The batch static binding experiments were carried out to estimate the adsorption kinetics, adsorption isotherms and selective recognition of the MIP particles. The adsorption behavior followed the pseudo-second order kinetic model, revealing that the process was chemically carried out. Two adsorption isotherm models were applied to analyze equilibrium data, obtaining the best description by Langmuir isotherm model. In addition, the MIP particles also could selectively recognize glutathione over similar analogs, indicating the possibility for the separation and enrichment of the template from complicated matrices.

关 键 词：Molecularly imprinted polymer Controlled living radical polymerization Particle size RECOGNITION Glutathione. 

分 类 号：O631.3[理学—高分子化学]