新生儿乙肝疫苗接种后无(弱)应答的影响因素研究  

A study on influencing factors of non-and low-response to hepatitis B vaccination in infants

作　　者：阿达力别克[1] 巴哈提古丽[2] 

机构地区：[1]新疆医科大学公共卫生学院流行病学与卫生统计学教研室,乌鲁木齐830011 [2]新疆医科大学昌吉市人民医院儿科,新疆昌吉831100

出　　处：《新疆医科大学学报》2015年第3期370-372,共3页Journal of Xinjiang Medical University

基　　金：新疆医科大学创新基金(XJC201120)

摘　　要：目的探讨新生儿乙肝疫苗接种后出现无（弱）应答的影响因素。方法选择2012-2014年出生的新生儿334例,按免疫程序接种3针乙肝疫苗,2个月后检测Anti-HBs,问卷调查了解孕期、婴儿出生、疫苗接种及出生后发育情况,分析出现无（弱）应答的影响因素。结果 Logistic回归分析显示,与新生儿乙肝疫苗无（弱）应答有关联的因素有母亲乙肝史（OR=2.045,95%CI：1.008～6.356）、新生儿发育状况（OR=5.001,95%CI：1.079～7.416）。结论新生儿乙肝疫苗接种后出现无（弱）应答是由多种因素导致的。有乙肝感染史的母亲应慎重妊娠、分娩及喂养孩子,新生儿要注意营养,确保正常发育。Objective To investigate the influencing factors of non-and low-response to hepatitis B vaccina- tion in infants. Methods 334 infants born during 2012-2014 were vaccinated with 3 dosage of hepatitis B vaccine according to schedule were selected as subjects. Anti-HBs were detected 2 months later, and related information of gestation period, birth, immunization, postnatal development were collected by questionnaires. Results Logistic regression analysis shows that history of maternal HB （OR = 2. 045, 95% CI： 1.008-6.356） and postnatal development （OR =5.001,95% CI： 1.079-7.416） were the factors of non-and low-response to hepatitis B vaccination in infants. Conclusion This study shows that non-and low-response to hepatitis B vaccination in infants were caused by a variety of factors. Mothers with a histo- ry of hepatitis B infection should be careful during pregnancy, child delivery, child feeding and pay more attention to newborn nutrition.

关 键 词：新生儿 乙肝疫苗 无弱应答 影响因素 

分 类 号：R17[医药卫生—妇幼卫生保健]