肿瘤中巨噬细胞表型极化的调控机制及中药干预的研究进展  

Advance in studies on regulatory mechanism of phenotype polarization of macrophages and intervention with traditional Chinese medicines

作　　者：王原来[1] 卞卡[1,2] 章丹丹[1] 

机构地区：[1]上海中医药大学穆拉德中药现代化研究中心,上海201203 [2]美国乔治华盛顿大学生物化学与分子生物学系,华盛顿20052

出　　处：《中国中药杂志》2015年第2期180-184,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金青年基金项目(81001666);上海市教育委员会科研创新项目(13YZ048);上海高校选拔培养优秀青年教师基金项目(SZY07029);上海市卫生和计划生育委员会科研课题(20144Y0143)

摘　　要：巨噬细胞具有异质性和多样性,可随所在的器官微环境和生理病理条件极化成不同的表型。M1经典性激活和M2替代性激活是巨噬细胞表型极端化后的2个主要亚群,分别表达不同的表面受体,分泌不同的细胞因子、趋化因子,受转录和表观遗传水平各个信号通路的调控,并在肿瘤发展中行使不同的功能,而中药有可能通过调控巨噬细胞表型极化而改善微环境。目前对于巨噬细胞极化途径产生的特异性标志和极化的分子机制尚在研究进程中,该文就目前国内外对于巨噬细胞表型极化和调控机制的研究进展进行综述及对中药干预进行展望。Macrophages are heterogeneous and diversified, and can be polarized into different phenotypes in various microenviron- ments and physiological or pathological conditions. Major macrophage subpopulations including classically activated（ M1 ） and aherna- tively activated（M2） macrophages, which represent different surface receptors, secret different cytokines and chemokines, are regulated by different signal paths of transcriptions and epigenetic levels, and play distinctive roles in tumor progress. TCMs may improve the mi- croenvironment by regulating phenotype polarization of macrophages. So far, specific biomarkers and polarized molecules mechanisms gen- erated through the macrophage polarization approach are still unclear. In this article, we merely summarize the advance in domestic and foreign studies on phenotype polarization of macrophages and regulatory mechanisms and look into the future of intervention with TCMs.

关 键 词：巨噬细胞 表型极化 调控机制 肿瘤 

分 类 号：R285[医药卫生—中药学]