红花黄色素注射剂不良反应文献分析  

Literature Analysis on Adverse Reactions of Saffower Yellower Injection

作　　者：李学林[1] 崔冠楠[1] 崔瑛[2] 

机构地区：[1]河南中医学院第一附属医院,郑州450000 [2]河南中医学院药学院,郑州450000

出　　处：《中国药房》2015年第6期732-734,共3页China Pharmacy

基　　金：河南省重点科技攻关计划--中药注射剂规范化应用研究(No.102102310077)

摘　　要：目的:探讨红花黄色素(SY)注射剂致不良反应(ADR)的一般规律和特点,为临床合理用药提供参考。方法:检索1979-2014年发表的有关SY注射剂致ADR病例报道,并就收集的ADR相关信息进行分类、统计和分析。结果:两种不同SY制剂在患者年龄、性别、发生时间方面均无明显差异,且致ADR均主要表现在变态反应方面,但SY氯化钠注射液致过敏性休克占比(24.39%)显著高于注射用SY(0.82%),循环系统损害占比(2.44%)显著低于注射用SY(22.13%)。结论:不论何种SY注射剂均需规范用药,同时加强用药监测,发生ADR时应及早对症处理,确保患者用药安全。OBJECTIVE： To investigate the general pattern and characteristics of the adverse reaction （ADR） of saffower yel- lower （SY） injection and provide reference for clinical rational drug use. METHODS： ADR cases of SY publicly reported during the period of 1979-2014 were collected for classification and statistical analysis. RESULTS： There were no significant differences among the age, gender and occurrence time in 2 different kinds of SY preparation. The main clinical manifestations of ADR was al- lergies, but the percentage of anaphylactic shock induced by SY sodium chloride injection （24.39%） was significantly higher than that of SY sodium chloride injection （0.82%） , circulatory system （2.44%） was significantly lower than that of SY injection （22.13%）. CONCLUSIONS： Regardless of the preparation, it requires standard medication and strengthening the monitoring of medication, and needs symptomatic treatment of ADR to ensure patient medication safety.

关 键 词：红花黄色素注射剂 不良反应 文献分析 

分 类 号：R969.3[医药卫生—药理学]