格列喹酮对比格列本脲治疗2型糖尿病有效性和经济性的系统评价  

Effectiveness and Economy of Gliquidone versus Glibenclamide in the Treatment of Type 2 Diabetes:Systematic Evaluation

作　　者：杨蕊[1] 崔学艳[1] 李妍[1] 王鹏[1] 李宏建[1] 苏乐群[1] 

机构地区：[1]山东省千佛山医院药学部,济南250014

出　　处：《中国药房》2015年第6期777-780,共4页China Pharmacy

基　　金：国家科技支撑计划课题(No.2013BAI06B04)

摘　　要：目的:系统评价格列喹酮对比格列本脲治疗2型糖尿病的有效性和经济性,以为临床治疗提供循证参考。方法:计算机检索Pub Med、Medline、EMBase、Cochrane图书馆、中国期刊全文数据库、中文科技期刊全文数据库、万方数字化期刊全文数据库,收集格列喹酮对比格列本脲治疗2型糖尿病的有效性和经济性的随机对照试验(RCT),采用Rev Man 5.2统计软件对有效性进行系统评价,采用Treeage pro 2011软件绘制决策树模型进行成本-效果分析。结果:有效性部分纳入4项RCT,合计150例患者。Meta分析结果显示,格列喹酮与格列本脲治疗2型糖尿病的疗效相当,在改善患者空腹血糖水平[MD=0.67,95%CI(-0.09,1.42),P=0.08]和糖化血红蛋白水平[MD=0.25,95%CI(-0.12,0.62),P=0.18]方面,差异无统计学意义。经济性研究发现,格列喹酮对比格列本脲的增量成本-效果比为1 159.56元/Hb A1c。结论:格列喹酮与格列本脲治疗2型糖尿病的疗效相当,格列本脲的经济性较好。由于纳入研究数量较少,该结论有待大样本、高质量的RCT进一步验证。OBJECTIVE： To evaluate the effectiveness and economy of gliquidone versus glibenclamide in the treatment of type 2 diabetes systematically, and to provide evidence-based reference for clinical treatment. METHODS： Retrieved from PubMed, Medline, EMBase, Cochrane Library, CNKI, VIP and Wanfang database, randomized controlled trials （RCT） about gliquidone vs. glibenclamide in the treatment of type 2 diabetes were collected; the effectiveness was evaluated by using Rev Man 5.2 software, and cost-effectiveness analysis was conducted with decision tree model drawn by Treeage pro 2011 software. RE- SULTS： 4 RCT were included, involving 150 patients in total. Results of Meta-analysis showed that therapeutic efficacy of gliqui- done was similar to glibenclamide in the treatment of type 2 diabetes, and there was no statistical significance in the improvement of FPG [MD=0.67,95%CI（--0.09, 1.42）,P=0.08] and HbA1c [MD=0.25,95%CI（--0.12,0.62） ,P=0.18]. Results of economy study showed, the incremental cost-effectiveness ratios （ICERs） of gliquidone vs. glibenclamide was 1 159.56 yuan/I-IbA1c. CON- CLUSIONS ： Therapeutic efficacy of gliquidone is similar to glibenclamide in the treatment of type 2 diabetes, glibenclamide has better economical efficiency. Due to the small number of included studies, it remains to be confirmed with large-samples and high-quality RCT.

关 键 词：格列喹酮 格列本脲 随机对照试验 有效性 经济性 系统评价 

分 类 号：R977.15[医药卫生—药品]