不同剂量注射用丁二磺酸腺苷蛋氨酸治疗病毒性肝炎的效果观察  

Efficacy observation of different doses of ademetionine1,4-butanedisulfonate for injection in treatment of viral hepatitis

作　　者：李伟健[1] 吴锐城 李颖[1] 

机构地区：[1]广东省普宁市人民医院感染科,广东普宁515300

出　　处：《中国当代医药》2015年第4期91-93,共3页China Modern Medicine

摘　　要：目的探讨不同剂量注射用丁二磺酸腺苷蛋氨酸治疗病毒性肝炎的临床效果。方法择取2010年8月~2014年9月本院收治的病毒性肝炎患者60例,将其随机分为对照组和实验组,两组均接受常规治疗,对照组施以1000 mg注射用丁二磺酸腺苷蛋氨酸,实验组给予2000 mg注射用丁二磺酸腺苷蛋氨酸,行静脉滴注,观察两组的临床治疗效果。结果实验组总有效率为96.67%,明显高于对照组的76.67%,差异有统计学意义（P〈0.05）。实验组血清总胆红素（TBi L）、丙氨酸氨基转移酶（ALT）、碱性磷酸酶（ALP）、谷氨酰转肽酶（GGT）水平显著低于对照组,差异有统计学意义（P〈0.05）;治疗期间,两组均未出现明显不良反应。结论于常规治疗的基础上对病毒性肝炎患者推行丁二磺酸腺苷蛋氨酸疗法,可改善预后,临床上应引起足够重视。Objective To investigate the efficacy of different doses of ademetionine1,4-butanedisulfonate for injection in treatment of viral hepatitis. Methods 60 patients with viral hepatitis treated in our hospital from August 2010 to September 2014 were selected,and were randomly divided into control group and experimental group,30 cases in each group,routine treatment was given to the two groups,while the control group was given with 1000 mg ademetionine1,4-butanedisulfonate for injection,experimental group were taken with 2000 mg ademetionine1,4-butanedisulfonate for injection.Clinical therapeutic effect of the two groups was compared. Results The total effective rate in experimental group was 96.67%,higher than 76.67% in control group,the difference was significant（P〈0.05）.TBIL,ALT,ALP,GGT level in experimental group was lower than that in the control group,the difference was significant（P〈0.05）.There was no significant adverse reaction occurred between the two groups. Conclusion On the basis of conventional treatment,ademetionine1,4-butanedisulfonate for injection therapy in patients with viral hepatitis may improve the prognosis,should pay attention in clinic.

关 键 词：常规治疗 丁二磺酸腺苷蛋氨酸 病毒性肝炎 临床疗效 安全性 

分 类 号：R512.6[医药卫生—内科学]