广陈皮水提物的化学成分分析  

Chemical Constituents from Citri Reticulatae Pericarpium

作　　者：唐维[1] 叶勇树[1] 王国才[1] 李药兰[1] 冯毅凡[2] 吴霞[2] 

机构地区：[1]暨南大学中药及天然药物研究所,广州510632 [2]广东药学院中心实验室,广州510006

出　　处：《中国实验方剂学杂志》2015年第4期30-33,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81202429;81273390;81473116);广东省自然科学基金项目(S2013020012864)

摘　　要：目的:研究广陈皮水提物的活性成分。方法:采用硅胶、Sephadex LH-20柱色谱和制备高效液相色谱对广陈皮的水提物进行分离,通过理化常数和波谱分析鉴定化合物的结构。结果:从广陈皮水提物中分离鉴定出7个化合物的结构,包括1个黄酮碳苷,2个二氢黄酮苷,2个多甲氧基黄酮,1个楝烷型降四环三萜和1个二糖,其结构分别鉴定为6,8-Di-C-β-葡糖基芹菜苷(1),橙皮苷(2),芸香柚皮苷(3),川陈皮素(4),橘皮素(5),柠檬苦素(6)和麦芽糖(7)。结论:化合物1和7为首次从该植物中分离得到。Objective： To investigate the chemical constituents in the aqueous extract of Citri Reticulatae Pericarpium. Method： The chemical constituents were isolated by several chromatographic methods, including silica gel, Sephadex LH-20 and preparative HPLC. Their structures were elucidated by their physical and spectral data. Result： Seven compounds were isolated, including one flavone C-glycoside, two flavanone glycosides, two polymethoxylated flavones, one meliacane and one disaccharide, and elucidated as follows： vicenin-2 （1）, hesperidin （2）, narirutin （3）, nobiletin （4）, tangeretin （5）, limonin （6）, maltose （7）.Conclusion： Compounds 1 and 7 were isolation from this species for the first time.

关 键 词：广陈皮 水提物 化学成分 色谱技术 

分 类 号：R284.1[医药卫生—中药学]