白龙灵沙汤对非小细胞肺癌免疫功能的影响  

Clinicai Efficacy of Bailong Lingsha Tang on Celluiar Immune Function in Patients with Advanced Non-small Cell Lung Cancer

作　　者：胡志萍[1] 甘宁[1] 张光顺[1] 陈焕朝[1] 李泽浩[1] 江建平[1] 付浩云 

机构地区：[1]湖北省肿瘤医院中西医结合科,武汉430079

出　　处：《中国实验方剂学杂志》2015年第4期182-185,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：湖北省卫生厅中西医结合科研基金项目(2012Z-B07)

摘　　要：目的:探讨中药白龙灵沙汤对非小细胞肺癌免疫功能的影响。方法:观察非小细胞肺癌60例,治疗组30例,对照组30例,治疗2个周期后进行比较。结果:与对照组比较,治疗组能够提高CD3+T细胞,CD4+T细胞百分比及CD4+/CD8+,降低CD8+T细胞百分比,提高NK细胞百分比,降低CD19+B淋巴细胞百分比。两组比较差异有显著性意义(P<0.05)。临床症状改善率治疗组为86.70%,而对照组为56.70%。两组比较差异有显著性意义(P<0.05)。治疗组与对照组相比能够显著提高行为状况评分,两组比较差异有显著性意义(P<0.05)。结论:中药白龙灵沙汤配合化疗能改善临床症状、提高生活质量,提高机体免疫功能。Objective： To observe the effect of Bailong Lingsha Tang （BLLST） on cellular immune function in the treatment of advanced non-small cell lung cancer. Method： Totally 60 patients with advanced non- small cell lung cancer were randomly divided into the control group and the treatment group of 30 patients each. Patients in the control group were treated by routine chemotherapy, while patients in the treatment group were treated by combination of BLLST and routine chemotherapy. Changes of KPS and symptom scores were observed in both groups. Result： Compared with the control group, percentage levels of CD3^＋, CD4^＋, CD4^＋/CD8^＋, and NK cells increased, percentage levels of CD8^＋, CD19^＋ decreased in the treatment group with significant difference （P 〈0.05） after 2-cycle chemotherapy, hnprovement of symptoms in the treatment group （86.70%） was higher than that in the control group （56.70%） with significant difference （ P 〈 0.05 ）. Improvement of KPS, quality of life in the treated group after treatment was superior to those in the control group with significant difference （P 〈 0.05）. Conclusion： Combination of BLLST and chemotherapy could increase the cellular immune function, improve and relax lesions symptoms, and improve the quality of life.

关 键 词：非小细胞肺癌 白龙灵沙汤 细胞免疫功能 化学治疗 

分 类 号：R287.6[医药卫生—中药学]