线粒体偶联因子-6与介入治疗后血管内膜增殖的关系  

Relationship between mitochondrial coupling factor 6 and degree of intimal hyperplasia after percutaneous coronary intervention

作　　者：郑华峰[1] 

机构地区：[1]北京大学深圳医院心内科,广东深圳518000

出　　处：《岭南心血管病杂志》2015年第1期28-31,共4页South China Journal of Cardiovascular Diseases

摘　　要：目的观察冠状动脉粥样硬化性心脏病(冠心病)患者支架植入术后线粒体偶联因子6(coupling factor 6,CF6)的变化规律,并探索冠心病患者支植入术后线粒体CF6的峰值与术后12个月随访时内膜增生程度的关系。方法临床上筛选符合入选条件的患者30例,分别于造影术前、造影术后即刻,经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗后即刻、术后1 d、术后3 d、术后7 d采血,用放射免疫方法检测CF6及6-酮-前列腺素F1α(prostaglandin F1α,PGF1α)的浓度;12个月后对患者进行随访,检测患者血浆CF6及6-酮-PGF1α浓度,并对患者进行冠状动脉造影复查,应用血管内超声(intravenous ultrasound,IVUS)检测内膜增生情况。结果入组患者PCI治疗后即刻血浆CF6浓度较术前有所升高,差异有统计学意义[(216.75±14.40)pg/m L vs.(231.75±13.2)pg/m L,P<0.05];并在术后1 d达到高峰[(263.2±14.08)pg/m L,P<0.05],3 d后开始下降[(239.75±13.20)pg/m L,P<0.05],7 d后可以恢复至造影前水平[(222.6±15.04)pg/m L,P>0.05]。PCI治疗后血浆CF6浓度与6-酮-PGF1α浓度明显负相关(P=-0.679,P<0.05)。术后1年随访时,血浆CF6浓度是(222.05±14.92)pg/m L,6-酮-PGF1α浓度是(24.05+2.64)pg/m L,内膜增生厚度为(159±0.015)mm。患者内膜增生厚度与PCI治疗后血浆CF6峰值浓度呈正相关(r=0.819,P<0.05),与6-酮-PGF1α峰值浓度呈负相关(r=-0.797,P<0.05)。结论 CF6浓度在PCI治疗后明显增高,并于术后1 d达高峰,3 d有所下降,7 d后回落至基线浓度,CF6浓度和6-酮-PGF1α浓度负相关。患者内膜增生厚度与PCI治疗后血浆CF6峰值浓度呈正相关,CF6术后峰值浓度越高,其远期内膜增生越严重。Objectives To investigate the variation of mitochondrial coupling factor 6（CF6） in patients with coronary heart disease after percutaneous coronary intervention（PCI） and explore the relationship between the degree of intimal hyperplasia and peak expression of CF6 in 12 months＇ follow-up. Methods Totally 30 patients with coronary heart disease meeting the inclusion criteria were included in this study. Concentrations of peripheral blood CF6 and 6-ketoprostaglandin F1α（PGF1α） were detected by radioimmunoassay before and immediately after angiography,before and immediately after PCI,as well as 1 day,3 days and 7 days after PCI. We detected plasma concentrations of CF6 and 6-keto- PGF1α in the same way after followed-up for 12 months,and intravenous ultrasound（IVUS） was used to detect coronary intimal hyperplasia. Results Plasma concentration of CF6 in patients with coronary heart disease increased significantly instantly after PCI compared with that of the pre-operation [（216.75±14.40） pg / m L vs.（231.75±13.2） pg / m L,P〈0.05 ],reached the peak level 1 day after PCI [（263.2 ±14.08） pg / m L,P〈0.05 ],declined in 3 days [（239.75 ±13.20） pg / m L,P〈0.05 ] and returned to the pre-angiography level in 7 days [（222.6±15.04） pg / m L,P〉0.05 ]. 6-ketoPGF1α was negatively correlated with plasma concentration of CF6（r =-0.679,P〈0.05）. In 12 months＇ follow-up after surgery,plasma concentration of CF6 was（222.05±14.92） pg / m L,plasma concentration of 6-keto-PGF1α was（24.05±2.64）pg / m L,and thickness of intimal hyperplasia was（159±0.015） mm. Thickness of intimal hyperplasia was positively correlated with peak level of plasma CF6 after PCI（r =0.819,P〈0.05）,and negatively correlated with peak level of plasma 6-keto-PGF1α（r =-0.797,P〈0.05）. Conclusions Concentration of CF6 in patients with coronary heart disease increases significantly after PCI,reaches the peak level 1 day after PCI,declines in 3 days and returns to the baseline level 7

关 键 词：冠状动脉疾病 血管成形术 经皮 经腔冠状动脉 内膜增殖 线粒体偶联因子6 

分 类 号：R541.4[医药卫生—心血管疾病]