冠心病患者血浆白细胞介素-6、单核细胞黏附分子浓度介入治疗前、后的变化  

Change of plasma concentrations of interleukin-6 and adhesion molecules on peripheral blood monocytes in patients with coronary heart disease before and after percutaneous coronary intervention

作　　者：余盛龙 郭惠庄 张稳柱 李健豪 雷汉东 梁嘉永 

机构地区：[1]广州市番禺中心医院心内科,番禺区心血管病研究所,广州511400

出　　处：《岭南心血管病杂志》2015年第1期40-42,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的分析冠状动脉粥样硬化性心脏病(冠心病)患者血浆白细胞介素-6、单核细胞黏附分子浓度在介入治疗前、后的变化,探讨炎症反应在冠心病发病机制的作用以及介入治疗后炎症反应的情况及其意义。方法入选行冠状动脉介入治疗的冠心病患者60例作为治疗组。其中,急性冠脉综合征(ACS)患者28例,稳定型心绞痛(SAP)患者32例。同时选择拟诊冠心病但冠状动脉造影正常者30例作为对照组。分别于冠状动脉介入治疗前、后测定所有入选患者血浆白细胞介素-6、单核细胞黏附分子的浓度。结果治疗前,治疗组血浆白细胞介素-6、单核细胞黏附分子浓度显著高于对照组,差异有统计学意义(P<0.05);而急性冠脉综合征亚组又明显高于稳定型心绞痛亚组,差异有统计学意义(P<0.05)。治疗后,血浆白细胞介素-6、单核细胞黏附分子浓度较术前明显升高,差异有统计学意义(P<0.05);对照组行冠状动脉造影术前、后血浆白细胞介素-6、单核细胞黏附分子浓度比较,差异无统学意义(P>0.05)。结论血浆白细胞介素-6、单核细胞黏附分子浓度在反映冠状动脉病变的严重程度方面有重要的参考意义;冠状动脉介入治疗后炎症反应加剧,可能在再狭窄的发生中有重要的作用。Objectives To analyze the change of plasma concentrations of interleukin-6（IL-6） and adhesion molecules on peripheral blood monocytes（ICAM） after percutaneous coronary intervention（PCI） in patients with coronary heart disease（CHD）,and to explore the role of inflammation in the mechanism of CHD and the significance of inflammation after PCI. Methods A number of 60 patients undergoing PCI for CHD were selected as treatment group [acute coronary syndrome（ACS） subgroup（n =28）,stable angina pectoris（SAP） subgroup（n =32） ]. Thirty healthy individuals with normal results by coronary angiography were selected as control group. Plasma concentrations of IL-6 and ICAM were measured before and after PCI or coronary angiography. Results Before treatment,plasma concentrations of IL-6 and ICAM of treatment group were significantly higher than those of control group（P〈0.05）; They were also significantly higher in ACS subgroup than in SAP subgroup（P〈0.05）. After treatment,plasma concentrations of IL-6 and ICAM in treatment group were significantly higher than those before PCI treatment（P〈0.05）; but they had no significant changes before and after coronary angiography in control group（P〉0.05）. Conclusions Plasma concentrations of IL-6 and ICAM play an important role in reflecting the severity of CHD. Exacerbated inflammatory may be important to the occurrence of in-stent restenosis among CHD patients undergoing PCI.

关 键 词：冠状动脉疾病 白细胞介素-6 单核细胞黏附分子 

分 类 号：R541.4[医药卫生—心血管疾病]