电子支气管镜三联注药联合化疗治疗耐多药肺结核疗效分析  

Analysis of multi-drug resistant pulmonary tuberculosis treated by electronic bronchoscope drug-injection combined with chemotherapy

作　　者：刘会[1] 张晓光[1] 安贺娟[1] 陈素丽[1] 王显雷[1] 张秀敏[1] 

机构地区：[1]河北省胸科医院结核内科,石家庄050041

出　　处：《国际呼吸杂志》2015年第4期261-264,共4页International Journal of Respiration

基　　金：河北省科技厅支撑计划项目（122777111）

摘　　要：目的分析针对耐多药肺结核患者的化疗方案联合支气管注药方案对该类患者的临床疗效。方法取本院2008--2011年收治耐多药肺结核患者80例，根据治疗方法不同随机分为观察组和对照组。两组均采用6LfxCmPaZPto／18LfxPaZPto化疗方案，观察组同时加用支气管镜三联注药治疗2个月。比较两组临床表现、细菌学及影像学表现等。结果观察组及对照组临床表现有效率差别不明显，但观察组的早期痰菌阴转情况、影像学吸收情况均优于对照组。结论对于耐多药肺结核患者，在应用核心化疗方案基础上早期给予局部支气管内电子支气管镜注药治疗能增加患者早期痰菌阴转率，促进病灶吸收。Objective To study the curative effects of electronic bronchoscope drug-injection eombined with chemotherapy in multi-drug resistant pulmonary tuberculosis. Methods 80 patients with multi-drug resistant pulmonary tuberculosis in our hospital from 2008 to 2011 were randomly divided into experience group and contol group. All patients adopt the same chemotherapy （6LfxCmPaZPto/18LfxPaZPto, and the experience group also received electronic bronchoscope drug-injection for two months. The clinical manifestations, sputum negative conversion rate at different times, and image performance of two groups were compared. Results There was no significant difference in the clinical manifestations between the two groups. The sputum negative conversion rate and the lesion absorption in the experience group were better than those in the control group. Conclusions Using electronic hronchoscope drug-injection earlier based on the core chemotherapy can increase the sputum negative conversion rate and improve the lesion absorption.

关 键 词：耐多药肺结核 电子支气管镜 

分 类 号：R521[医药卫生—内科学]