双侧小脑上脚各向异性分数与年龄相关性的初步研究  

Preliminary study of age-related changes in fractional anisotropy of bilateral superior cerebellar peduncles with MR diffusion tensor imaging

作　　者：吴珂[1] 王君霞[2] 马得廷[1] 张有军[1] 谢元忠[1] 

机构地区：[1]山东省泰安市中心医院医学影像部,271000 [2]山东省泰安市中心医院产科,271000

出　　处：《中华临床医师杂志（电子版）》2015年第3期69-71,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的应用磁共振弥散张量成像（DTI）定量评估双侧小脑上脚各向异性分数（FA）值，并探讨与年龄之间的相关性。方法回顾性分析110例健康受检者DTI图像数据，男54例，女56例，14-79岁，平均50．8岁。由一名专家运用感兴趣区（ROD功能在FA图上测量双侧小脑上脚的FA值。双侧小脑上脚的FA值的比较采用配对样本t检验，FA值与年龄的相关性采用双变量相关分析。结果110例健康者中，双侧小脑上脚的FA值分别为0．707±0．050、0．712±0．050，无统计学差异（t=-1．829，P=0．000）。右侧小脑上脚FA值与年龄呈正相关（r=O．400，P=0．000），左侧小脑上脚FA值与年龄呈正相关（r=0．432，P=0．000）。结论双侧小脑上脚的FA值均与年龄呈正相关性，反映了小脑上脚随年龄的生理变化过程，可为相关研究提供参考。Objective This study is to evaluate the fractional anisotropy （FA） values of bilateral superior cerebellar peduncle （SCP） and explore the relationship between patient＇s age and FA value of the SCPs. Methods Axial FA maps of 110 neurologically normal subjects （54 men, 56 women; age range： 14-79 years, mean age： 50.8 years） using diffusion tensor imaging （DTI） were evaluated retrospectively. Measurement of the FA values was done by one radiologist and by placing circular ROIs in the SCPs. Paried-Sample t-test was used to evaluate the difference of FA values of bilateral SCPs. Bivariate correlation analysis was performed to evaluate the effects of age. Results In 110 healthy patients, the mean FA value was slightly lower in the right SCP （0.707±0.050） than in the left SCP （0.712±0.050）, the difference was not significant （t=-1.829, P=-0.000）. Bivariate linear regression models revealed that there was a moderate positive correlation between age and the FA value in the right SCP （r=0.400, P=0.000） and left SCP （r=0.432, P=0.000）. Conclusion The FA value of the bilateral SCPs has a positive correlation with age, reflecting the age-related changes of physiological processes, which could serve as a basis for SCP research.

关 键 词：磁共振成像 弥散 各向异性 小脑上脚 

分 类 号：R445.2[医药卫生—影像医学与核医学]