基于聚类分析的慢性阻塞性肺疾病稳定期用药规律探讨  

Exploration of Regularity of Treating Stable COPD Based on Cluster Analysis

作　　者：吴建军[1] 李欣[2] 秦阳[1] 

机构地区：[1]北京中医药大学第三附属医院,北京100029 [2]中国中医科学院眼科医院,北京100040

出　　处：《中医药导报》2015年第4期11-13,17,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：北京中医药大学自主选题资助项目(2014-JYBZZJS-066);北京中医药科技发展项目(JJ2013-55)

摘　　要：目的:探讨中医药治疗慢性阻塞性肺疾病稳定期的常用药物和配伍规律。方法:以1991年1月至2013年12月在省级以上期刊发表,以中医药为主用于慢性阻塞性肺疾病稳定期的治疗,且经过临床疗效观察有效的中药复方为研究对象,对其用药进行聚类分析,探索中医药治疗慢性阻塞性肺疾病稳定期的常用药物和配伍规律。结果:慢性阻塞性肺疾病稳定期使用最多的药物为黄芪、甘草、茯苓、党参、陈皮、半夏、白术。聚类分析显示慢性阻塞性肺疾病稳定期常用药物可分为4类,包括补益肺脾、补肺益肾、活血化瘀、清肺止咳化痰药物。结论:慢性阻塞性肺疾病稳定期的用药以益气、养阴、活血,清肺化痰类中药为主,益气阴化痰瘀是慢性阻塞性肺疾病稳定期的基本治疗方法。Objective： To explore the commonly used drugs and its law of compatibility in treatment of stable COPD. Meth-ods： TCM compound was taken to study, which was effective in clinical and the main treatment of stable COPD published in1991 January to 2103 December on the journal. Cluster analysis was performed on the drug, to explore the commonly used drugs and law of compatibility of TCM in treatment of stable COPD. Results： The most frequently used drugs in TCM treating stable COPD were Astragalus, Licorice, Poria, Codonopsis pilosula, Tangerine, Pinellia and Atractylodes. Clustering analysis showed that the drugs could be divided into four categories, including invigorating lung and spleen, invigorating lung and kidney,promoting blood circulation for removing blood stasis, clearing lung and eliminating phlegm. Conclusion： The main drugs treating stable COPD should focus on the effects of supplementing qi, nourishing yin, promoting blood circulation, clearing lung and e-liminating phlegm. Therefore, supplementing qi and nourishing yin, promoting blood circulation and eliminating phlegm is the basic method in the treatment of stable COPD.

关 键 词：慢性阻塞性肺疾病稳定期 用药规律 聚类分析 中医药 

分 类 号：R256.1[医药卫生—中医内科学]