单链抗体的研究进展及其应用  

Research Progress on Single-chain Antibody and Its Application

作　　者：黄静[1] 张括川 刘晓丹[1] 王琳[1] 张璐[1] 赵宝华[1] 

机构地区：[1]河北师范大学生命科学学院,河北石家庄050024

出　　处：《畜牧与饲料科学》2014年第11期49-52,共4页Animal Husbandry and Feed Science

基　　金：河北省自然科学基金项目(2009000290)

摘　　要：随着分子生物学的发展,单链抗体作为一种小分子基因工程抗体,在理论和应用方面的研究引起了广泛的关注,其在显像定位诊断、靶向治疗和参与细胞免疫等方面展示出了可观的应用前景。对单链抗体的结构及特点、制备技术及其应用等进行了综述,以期能够为单链抗体的进一步深入研究和应用提供理论基础。With the development of molecular biology, the theoretical and application studies on single-chain antibody as a micro-molecule antibody prepared by genetic engineering have attracted wide attentions. And it showed considerable application prospects in imaging localization and diagnosis, targeted therapy and cellular immunity. The structure, characteristics and preparation technology of single-chain antibody as well as its applications were reviewed, so as to provide theoretical foundation for further study on single-chain antibody and its applications.

关 键 词：单链抗体 结构 制备技术 研究进展 应用前景 

分 类 号：Q511[生物学—生物化学] R392.11[医药卫生—免疫学]