高渗盐水联合甘露醇对脑出血早期脑水肿患者的临床疗效观察  

Clinical effects of hypertonic saline and mannitol in treatment of early cerebral edema followed by cerebral hemorrhage

作　　者：狄剑秋[1] 管峥峰[1] 雷鹏[1] 

机构地区：[1]溧阳市中医院神经外科,江苏溧阳213300

出　　处：《现代医学》2014年第11期1351-1353,共3页Modern Medical Journal

摘　　要：目的:探讨高渗盐水联合甘露醇治疗脑出血早期脑水肿的临床疗效。方法:将160例脑出血早期脑水肿患者随机分为观察组与对照组,对照组采用20%复方甘露醇注射液常规治疗,观察组在对照组用药基础上同时联合应用高渗盐水。对两组患者治疗前后脑水肿、血肿及神经功能评分进行比较。结果:两组患者经治疗后脑水肿及血肿体积均缩小(P<0.05),观察组缩小更明显(P<0.05);神经功能缺损程度(NIHSS)评分均增加(P<0.05),观察组增加更明显(P<0.05)。显效率观察组为65.0%,对照组为41.3%,观察组优于对照组(P<0.05)。结论:高渗盐水联合甘露醇可以更有效地促进脑出血早期脑水肿的吸收,改善患者的神经功能。Objective： To investigate clinical effects of hypertonic saline joint mannitol in treatment of early cerebral edema followed by cerebral hemorrhage. Methods： One hundred and sixty cases of cerebral hemorrhage combined with early cerebral edema were randomly divided into the treatment group and the control group. All cases were treated by appropriate symptomatic treatment, then the control group was given mannitol therapy, the treatment group was treated with hypertonic saline and mannitol. The size of cerebral edema volume, hematoma and NIHSS scores in the two groups of patients before and after treatment were calculated. Results： After treatment, the size of cerebral edema volume and hematoma in both groups were significantly decreased （ P 〈 0. 05 ）, and the treatment group improved more significantly （P 〈 0. 05 ） ; NISHH score was significantly better （ P 〈 0. 05 ）, and more improvement in the treatment group （P 〈 0. 05 ）. The efficiency in treatment group was 65.0%, while in the control group was 41.3%. The results of the evaluation of the treatment group were significantly better （P 〈 0. 05）. Conclusion： Hypertonic saline and mannitol can possibly promote the absorption of cerebral edema, and improve the patients＇ neurological function.

关 键 词：高渗盐水 甘露醇 脑出血 早期脑水肿 疗效 

分 类 号：R651.11[医药卫生—外科学]