Electrochemical Reaction Mechanism of Phenacetin at a Carboxylated Multiwall Carbon Nanotube Modified Electrode and Its Analytical Applications  

作　　者：ZHANG Jinlei LAN Cuiling SHI Bingfang LIU Fang ZHAO Dandan TAN Xuecai 

机构地区：[1]Department of Chemistry and Life Science, Baise University, Baise 533000, t~ R. China," [2]School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530008, P. R. China

出　　处：《Chemical Research in Chinese Universities》2014年第6期905-909,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（Nos.41063007, 21365004）, the Natural Science Foundation of Guangxi Zhuang Autonomous Region, China（Nos.2010GXNSFB013001, 2013GXNSFDA019006） and the Project of the Edu- cation Department of Guangxi Zhuang Autonomous Region, China（No.201103YB130）.

摘　　要：A novel type of carboxylated multiwalled carbon nanotube modified electrode（c-MWCNTs/GCE） was constructed and the electrochemical properties of phenacetin（PHE） at it were studied. In a buffer solution of 0.1 mol/L HAc-NaAc（pH=5.3）, PHE exhibited a couple of quasi-reversible redox peaks and an anodic peak in the poten- tial range of 0.2--1.2 V at c-MWCNTs/GCE. The peak current was proportional to the concentration of PHE in the range of 4.0× 10^-6_ 1.0 × 10^-4 mol/L with a detection limit of 1.0× 10^-6 mol/L（S/N=3）. The c-MWCNTs/GCE showed excellent repeatability and stability and the electrochemical reaction mechanism of PHE was proposed. This method was used to determine the content of PHE in medical tablets and the recovery was determined to be 96.5%--104.2% by means of a standard addition method.A novel type of carboxylated multiwalled carbon nanotube modified electrode（c-MWCNTs/GCE） was constructed and the electrochemical properties of phenacetin（PHE） at it were studied. In a buffer solution of 0.1 mol/L HAc-NaAc（pH=5.3）, PHE exhibited a couple of quasi-reversible redox peaks and an anodic peak in the poten- tial range of 0.2--1.2 V at c-MWCNTs/GCE. The peak current was proportional to the concentration of PHE in the range of 4.0× 10^-6_ 1.0 × 10^-4 mol/L with a detection limit of 1.0× 10^-6 mol/L（S/N=3）. The c-MWCNTs/GCE showed excellent repeatability and stability and the electrochemical reaction mechanism of PHE was proposed. This method was used to determine the content of PHE in medical tablets and the recovery was determined to be 96.5%--104.2% by means of a standard addition method.

关 键 词：Carboxylated multiwalled carbon nanotube Modified electrode PHENACETIN 

分 类 号：TQ460.6[化学工程—制药化工] TB383[一般工业技术—材料科学与工程]