儿童哮喘发作与呼吸道合胞病毒感染关系研究  

Study on the relationship between respiratory syncytial viral infection and the onset of asthma of children

作　　者：吴让琼[1] 陈宇宁[1] 

机构地区：[1]成都市新都区人民医院儿科,成都610500

出　　处：《国际病毒学杂志》2014年第6期277-279,共3页International Journal of Virology

摘　　要：目的 探究儿童哮喘疾病的发作与呼吸道合胞病毒（RSV）感染关系,为临床诊断及治疗提供依据.方法 采用间接酶联免疫吸附试验（ELISA）方法对来我院就诊的1 19例儿童哮喘患者和27例健康儿血清中RSV特异性IgG、IgM抗体进行检测,同时对RSV-IgM阳性患儿和正常对照组做血清RSV-IgE检测,并用微量细胞抑制法测定其血清干扰素（IFN-γ）水平并分析数据.结果 119例哮喘组中检出RSV-IgG和RSV-IgM总阳性例数81例,阳性率为68.1％,与正常对照组相比有显著性差异（P＜0.05）.32例RSV-IgM阳性者的平均血清RSV-IgE浓度与正常对照组相比也有显著性差异（P＜0.05）,而哮喘组IFN-γ水平明显低于正常对照组,亦有显著性差异（P＜0.05）.RSV-IgM与血清IgE呈正相关,与IFN-γ呈负相关.结论 儿童哮喘的发作与RSV感染关系密切,其机制与病毒感染损伤呼吸道黏膜、Ⅰ型变态反应的发生和免疫调节因子IFN-γ水平降低等有关.Objective To explore the relationship between onset of asthma of children with respiratory syncytial virus （RSV） infection and provide the basis for clinical diagnosis and treatment.Methods 119 cases of children with asthma and 27 healthy children in our hospital were collected as research subject and control subject.RSV-specific serum IgG,IgM antibodies were detected using indirect enzyme-linked immunosorbent assay （ELISA） method.For RSV-IgM positive cases,serum RSV-IgE was need detecting and analyzing the data.Results RSV-IgG and RSV-IgM total positive rate was 68.1% and there was a significant difference （P 〈0.00） compared with the control group.There was a significant difference （P 〈0.01） between RSV-IgE concentrations and the control group.IFN-γlevels of asthma group was significantly lower than that of the control group,there was significant difference （P 〈 0.01）.Conclusions There was close relationship between asthma outbreak with RSV infection.

关 键 词：儿童哮喘 呼吸道合胞病毒 特异性抗体 干扰素 

分 类 号：R725.6[医药卫生—儿科]