湛江地区中老年人群骨质疏松性骨折的流行病学调查与分析  

Epidemiological investigation and analysis of middle-aged and senile osteoporotic fracture in Zhanjiang area

作　　者：李广盛[1] 陈广谋 郑锦畅[1] 曾俏燕 牛艳茹[1] 林颢[1] 魏波[1] 楚佳奇 曾荣[1,2] 

机构地区：[1]广东医学院附属医院骨科,广东湛江524001 [2]广东医学院附属医院干细胞研发与细胞治疗中心,广东湛江524001

出　　处：《国际检验医学杂志》2014年第24期3304-3306,共3页International Journal of Laboratory Medicine

基　　金：广东省科技计划项目(2011B031800212);广东省自然科学基金(S2011020002426);广东医学院附属医院青年科研基金项目(20091c11)

摘　　要：目的：通过对湛江市广东医学院附属医院骨科住院治疗诊断为骨质疏松患者的调查分析，为预防骨质疏松性骨折的发生提供理论依据。方法年龄在40岁以上的中老年人，均为久居本地区，2012年8月至2014年2月到广东医学院附属医院骨科住院治疗的骨质疏松者，调查内容包括一般情况调查、医学检查、静脉血检测及骨密度检测。结果骨折组平均年龄大于非骨折组；非骨折组腰椎骨密度（LSBMD）和股骨颈骨密度（FNBMD）的 T、Z 值和血清钙水平大于骨折组并且差异均有统计学意义（P＜0.05）。骨折组内以性别分成两组进行对比，其中女性年龄大于男性且差异有统计学意义（P ＜0.05），男性 LSBMD 的 T 和 Z值和 FNBMD T 值大于女性且差异有统计学意义（P ＜0.05）。按10岁为一年龄段分组，分析各年龄组中骨折与非骨折例数，＞70～80岁组骨折患者最多；分析各年龄组 LSBMD、FNBMD、血清钙和维生素 D 水平，非骨折组高于骨折组（P ＜0.05）。通过对骨折的影响因素进行非条件 Logistic 回归分析，明确年龄、腰椎骨密度、股骨颈骨密度 T 值升高是骨折的危险因素，而维生素 D、股骨颈骨密度、腰椎骨密度 T 值升高是骨折的保护因素。结论骨质疏松需及早预防，尤其在40岁以前进行，尽量提高骨密度峰值，防止日后出现骨质疏松症。Objective Through the research and analysis of guangdong medical college affiliated hospital orthopaedic hospitalized patients with a diagnosis of osteoporosis in Zhanjiang,this paper provide theoretical basis for the prevention of osteoporosis frac-ture.Methods The elderly aged over 40 years old,living in this area for a long time.Data was collected from August 2012 to Feb-ruary 2014,hospitalized patients in guangdong medical college affiliated hospital were diagnosed with osteoporosis.Contents include general situation survey,medical examination,venous blood tests and bone mineral density testing.Results Fracture group average age is older than the non fracture group;the fracture group lumbar spine bone mineral density（LSBMD）and femoral neck bone min-eral density（FNBMD）T value and Z value and serum calcium group is greater than the fracture and the differences were statistically significant（P 〈0.05）.Fracture group in gender divided into two groups for comparison,in which women older than men,and the difference was statistically significant（P 〈0.05）,male LSBMD T and Z values and FNBMD T value is greater than the female and the difference was statistically significant（P 〈0.05）.According to the 10 year age group,Each age group compared with the frac-ture number and non fracture number,in the age group of 70-80 fracture number were the most;All age groups in LSBMD,FNB-MD,serum calcium（Ca）and VitD compared,non fracture group is most higher than that of fracture group.The influence factors of the fractures for non conditional Logistic regression analysis,age,LSBMD,FNBMD T value increased were risk factors for fracture, VitD,FNBMD,LSBMD T value increased were protective factors of fracture.Conclusion Need as soon as possible to prevent osteo-porosis,especially before the age of 40,try to improve the peak bone density,to prevent the occurrence of osteoporosis in the future.

关 键 词：骨质疏松 骨质疏松骨折 骨密度 血清钙 碱性磷酸酶 

分 类 号：R580[医药卫生—内分泌]