类风湿因子及Anti-CCP与患者临床免疫学特征的关系分析  

Analysis of relationship between rheumatoid factor and anti-CCP with clinical immunology characteristics

作　　者：陆亚[1] 陈璟[1] 凌雨[1] 张翠平[1] 

机构地区：[1]淮安市中医院检验科,江苏淮安223001

出　　处：《国际检验医学杂志》2014年第24期3371-3372,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨类风湿因子(RF)、抗环状瓜氨酸肽抗体(Anti-CCP)与患者临床免疫学特征之间存在的相关性。方法选取2012年5月至2014年7月在该院门诊就诊及住院的178例类风湿关节炎患者作为研究对象,并对患者的RF、Anti-CCP两项指标进行检测。结果患者中RF呈现阳性的比例为94.94%(169/178),Anti-CCP呈现阳性的比例为79.78%(142/178);病程超过1年患者占73.03%(130/178),类风湿关节炎患者的病程与Anti-CCP抗体现阳性率呈相关(P<0.05),与RF阳性率不存在相关性(P>0.05)。结论类风湿因子特异性较弱,抗环状瓜氨酸肽抗体(Anti-CCP)特异性突出,对早期诊断和临床治疗中发挥着极大的作用和价值,并和类风湿关节炎患者病情的严重性存在正相关关系。Objective To explore and evaluate the relationship between rheumatoid factor（RF）and anti-cyclic citrullinated pep-tide antibody（anti-CCP）with the patient′s immunological characteristics.Methods 178 patients with rheumatoid arthritis in our hospital from May 2012 to May 2014 were selected as the research subjects and detected the various clinical indicators.Results A-mong the patients,the proportion of RF positive was 94.94%（169/178）and which of anti-CCP positive was 79.78%（142/178）;the cases of disease course for more than 1 year accounted for 73.03%（130/178）,which had the correlation with the proportion of anti-CCP positive（P 〈0.05）,and RF had no correlation（P 〉0.05）.Conclusion RF has weaker specificity and anti-CCP antibody has prominent specificity,which play an enormous role and great value for early diagnosis and treatment,and have a positive correlation with the severity of rheumatoid arthritis.

关 键 词：类风湿因子 抗环状瓜氨酸肽抗体 临床免疫学 

分 类 号：R446.6[医药卫生—诊断学]