慢性阻塞性肺疾病患者牙周病及外周血、龈沟液炎性标志物观察  

Oral Hygiene Status and Observation of Inflammatory Factors in Peripheral Blood and Gingival Crevicular Fluid of Chronic Obstructive Pulmonary Disease

作　　者：李方治[1] 侯春阳[2] 王笑歌[1] 

机构地区：[1]中国医科大学附属第四医院呼吸内科,沈阳110032 [2]沈阳市第六人民医院内科,沈阳110006

出　　处：《临床误诊误治》2014年第12期74-77,共4页Clinical Misdiagnosis & Mistherapy

基　　金："十一五"国家科技支撑计划(2009BAI18B02)

摘　　要：目的观察慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者牙周病(牙周指标)及外周血、龈沟液(gingival crevicular fluid,GCF)炎性标志物情况。方法选取2012年1月—2013年10月在中国医科大学附属第四医院呼吸内科门诊和(或)住院治疗的COPD患者51例作为COPD组及同期健康体检的57例作为对照组。两组均行牙周检查及外周血、GCF白细胞介素(IL)-1β、IL-6、肿瘤坏死因子(TNF)-α和超敏C反应蛋白(hsCRP)检测并进行比较。结果牙周病患病率COPD组、对照组分别为56.86%(29/51)、21.05%(12/57),差异有统计学意义(χ2=14.66,P<0.01)。COPD组的牙周指标中临床附着丧失、牙周袋深度、牙龈指数、龈沟出血指数、菌斑指数、牙齿松动度、牙齿填充指数及简化口腔卫生指数均明显低于对照组(P均<0.05);COPD组外周血IL-1β、IL-6、TNF-α、hs-CRP和GCF IL-1β、IL-6、TNF-α水平均显著高于对照组(P均<0.05)。结论 COPD患者牙周卫生状况差,牙周病患病率高,外周血及GCF炎性标志物表达水平明显升高。Objective To compare the oral hygiene status and the observation of inflammatory factors in the peripher-al blood and gingival crevicular fluid （GCF） of chronic obstructive pulmonary disease （COPD）. Methods 51 COPD pa-tients and 57 healthy controls were selected from the outpatient department and wards of Department Respiratory Diseases of the Fourth Affiliated Hospital of China Medical University during January 2012 to October 2013. Periodontal examination and measurements of inflammatory factors, including IL-1β, IL-6, TNF-αand hs-CRP, in the peripheral blood and GCF were de-tected in the two groups. Results The periodontitis prevalence of COPD group （56. 86%, n=29） was significantly higher than that of control group （21. 05%, n=12） （χ2 =14. 66, P〈0. 01）. The clinical attachment loss, periodontal probing depth, gingival index, sulcular bleeding index, plaque index, tooth mobility, dental fillings index and simplified oral hygiene index of the COPD group were significantly lower than those of the control group （P〈0. 05）. IL-1β, IL-6, TNF-α and hs-CRP in the peripheral blood of COPD group were notably higher than those of the control group;in addition, the GCF, IL-1β, IL-6 and TNF-α in the COPD group were still higher than those of control group （P〈0. 05）. Conclusion The oral hygiene status is poor in COPD patients, which increases the prevalence of periodontal disease. Therefore the expression levels of in-flammatory factors in peripheral blood and GCF are significantly increased.

关 键 词：肺疾病 慢性阻塞性 牙周疾病 炎性因子 外周血 龈沟液 

分 类 号：R563.9[医药卫生—呼吸系统] R781.4[医药卫生—内科学]