阿尔茨海默病患者静息态功能磁共振信号活动强度的研究  

Resting state functional magnetic resonance imaging signal activity strength in patients with Alzheimer's disease

作　　者：周波[1] 张增强[1] 安宁豫[2] 姚洪祥[2] 王盼[1] 郭艳娥[1] 尚延昌[1] 高广生 张熙[1] 

机构地区：[1]解放军总医院南楼神经内科,北京100853 [2]解放军总医院南楼放射科,北京100853 [3]哈尔滨第四医院老年病科

出　　处：《中华老年心脑血管病杂志》2014年第12期1235-1237,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(81471120;60831004;61431012);军队"十二五"保健专项课题(13BJZ50);解放军总医院科技创新苗圃基金(13KMM19)

摘　　要：目的研究静息状态下阿尔茨海默病(Alzheimers disease,AD)患者静息态功能磁共振信号活动强度的变化情况。方法选择AD患者35例(AD组)及认知功能正常的健康体检者27例(对照组),进行静息状态下功能磁共振扫描,比较2组静息态功能磁共振信号时间域振幅的差异。结果在校正了年龄和性别的影响后,与对照组比较,AD组后扣带回的静息态功能磁共振信号时间域振幅强度减弱(11.88±4.43 vs 14.43±4.92,P<0.05)。结论AD患者后扣带回静息状态脑局部自发活动存在显著异常,这种通过时间域信号强度反映的变化为AD的早期诊断研究提供了有益的帮助。Objective To study the changes of resting state functional magnetic resonance imaging （fMRI） signal activity strength in patients with Alzheimer＇s disease （AD）.Methods Thirty-five AD patients served as an AD group and 27 subjects with normal cognition served as a control group in this study.The 2 groups underwent resting state fMRI.The amplitudes in the time domain of resting state fMRI signals were compared.Results The amplitude in the time domain of resting state fMRI signals in posterior cingulate cortex （PCC） was lower in AD group than in control group after adjustment for age and gender （11.88±4.43 vs 14.43±4.92,P＜0.05）.Conclusion The significantly different local cerebral spontaneous activity strength in PCC of AD patients contributes to the early diagnosis of AD.

关 键 词：阿尔茨海默病 磁共振波谱学 认知 早期诊断 神经心理学测验 

分 类 号：R749.16[医药卫生—神经病学与精神病学]