基于超声心动图的钙化性主动脉瓣疾病患病情况的回顾性研究  

Echocardiography-based retrospective analysis of calcific aortic valve disease

作　　者：NGOMERO Siza 曾庆春 许志浩[2] 朱丁季 王鹏[2] 刘俭[2] 詹琼[2] 赖文岩[2] 许顶立[2] 

机构地区：[1]南方医科大学,广州2011级硕士研究生510515 [2]南方医科大学南方医院心内科

出　　处：《中华老年心脑血管病杂志》2014年第12期1287-1289,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的 分析钙化性主动脉瓣疾病（CAVD）的患病情况.方法 收集并回顾性分析行超声心动图检查年龄≥45岁患者的临床资料17 826例,男性9725例,女性8101例,其中45～64岁11 274例,65～74岁4250例,75～84岁2052例,≥85岁250例.结果 CAVD总患病率为12.8％,男性CAVD患病率明显高于女性（13.6％ vs11.9％）,CAVD发生年龄明显低于女性[（70±10）岁vs （71±10）岁,P=0.001].CAVD患病率随着年龄增长明显增高,45～64岁,65～74岁,75～84岁,≥85岁4个年龄段患病率分别为5.3％、20.5％、32.9％和54.4％.CAVD患者最常受累及的瓣叶为无冠瓣,其次是右冠瓣＋无冠瓣、右冠瓣和左冠瓣.CAVD患者常见的功能异常为主动脉瓣反流,且主动脉瓣反流较狭窄明显多见（77.1％ vs 15.0％,P＜0.01）.CAVD患者左心房扩大发生率明显高于左心室扩大（56.3％ vs 22.2％）,室间隔肥厚发生率明显高于左心室后壁（51.7％ vs 24.2％,P＜0.01）.结论 CAVD患病率随年龄增长显著增高.Objective To analyze the incidence of calcific aortic valve disease （CAVD）.Methods The clinical data of 17826 patients aged ≥45 years who underwent echocardiography were retrospectively analyzed.Of the 17826 patients,9725 were male,8101 were female,11 274 aged 45-64years,4250 aged 65-74 years,2052 aged 75-84 years and 250 aged ≥85 years.Results The total incidence of CAVD was 12.8％ （99％CI：0.12-0.13）.The incidence of CAVD was significantly higher in male patients than in female patients （13.6％ vs 11.9％,P＜0.05）.The age to develop CAVD was younger in male patients than in female patients （70± 10 years vs 71 ±10 years,P=0.001）.The incidence of CAVD increased with the increasing age,and was 5.3％,20.5％,32.9％ and 54.4％ in 45-64,65-74,75-84 and ≥85 years old patients.The most commonly involved aortic valve in CAVD patients was the noncoronary leaflet,followed by the right leaflet ＋ noncoronary leaflet,right leaflet,and left leaflet.The most common dysfunction in CAVD patients was aortic valve regurgitation.The incidence of aortic valve regurgitation was higher than that of aortic valve stenosis （77.1％ vs 15.0％,P＜0.01）.The incidence of enlarged left atrium was higher than that of left ventricle （56.3％ vs 22.2％,P＜0.01）.The incidence of interventricular wall hypertrophy was higher than that of left ventricle posterior wall hypertrophy （51.7 ％ vs 24.2 ％,P＜0.01）.Conclusion The incidence of CAVD increases with increasing age.

关 键 词：超声心动描记术 主动脉瓣狭窄 主动脉瓣关闭不全 肥大 左心室 

分 类 号：R540.45[医药卫生—心血管疾病] R542.52[医药卫生—内科学]