川楝子正丁醇部位对小白鼠的急性毒性  

Acute Toxicity for Mice of the N-butyl Alcohol Extraction from Melia toosendan

作　　者：陈敏[1,2] 易文燕 俸婷婷[2,3,4] 周英[2,3,4] 

机构地区：[1]铜仁职业技术学院,贵州铜仁554300 [2]贵州省中药民族药创制工程中心,贵州贵阳550025 [3]贵州大学中药天然药研发中心,贵州贵阳550025 [4]贵州大学药学院,贵州贵阳550025

出　　处：《贵州农业科学》2015年第1期108-110,共3页Guizhou Agricultural Sciences

基　　金：教育部新世纪人才支持计划项目(NCET-11-0926);贵州省优秀青年科技人才培养对象专项资金[黔科合人字2011(34)];贵州省药食同源植物资源研究开发中心[黔科合G字(20714)4003]

摘　　要：为探明川楝子正丁醇部位的急性毒性,通过预试验测定出川楝子正丁醇部位的最小全死量（Dm）和最大全不死量（Dn）,然后进行川楝子正丁醇部位对小白鼠的急性毒性试验。结果表明：川楝子乙醇提取物的正丁醇部位对小白鼠单次口服的半数致死量（LD50）为2.757 1g/kg,95%可信限为2.741 9-2.772 3g/kg。死亡小白鼠急性毒性主要表现为安静少动、腹卧昏睡、呼吸急促、连续抽搐。川楝子正丁醇部位毒性较低,符合低毒化合物标准（500-5 000mg/kg）。To evaluate the acute toxicity of the n-butanol fraction from M.toosendan,minimum amount of Dm and the maximum amount of Dn of the n-butanol fraction from M.toosendan was measured by preliminary test.Then design a test to evaluate the acute toxicity for mice.The results showed that the LD50 of n-butanol fraction from M.toosendan on single dose in mice was 2.757 1g/kg,95% confidencelimit was 2.741 9-2.772 3g/kg.The main acute toxicity symptoms and signs of dead mice included negligent action,shortness of breath,continuous convulsions.According to the national standard of acute toxicity test,the n-butanol fraction from M.toosendan belonged to low-toxic compounds.

关 键 词：川楝子 正丁醇部位 急性毒性 半数致死量 

分 类 号：S567[农业科学—中草药栽培] R285.5[农业科学—作物学]