CT引导经黄韧带颈后路注射臭氧联合胶原酶治疗颈椎间盘突出症的疗效分析  

THE EFFICACY OF TREATMENT OF CERVICAL DISC HERNITATION BY POSTERIOR LIGAMENT FLAVA INJECTION OF OZONE AND COLLAGENASE UNDER CT-GUIADENCE

作　　者：赵家贵[1] 朱本藩[1] 宋阳[1] 赵丽[1] 陈家骅[1] 

机构地区：[1]安徽医科大学第一附属医院疼痛科,合肥230022

出　　处：《中国疼痛医学杂志》2015年第1期43-46,50,共5页Chinese Journal of Pain Medicine

摘　　要：目的:观察CT引导下采用颈后路注射臭氧联合胶原酶治疗颈椎间盘突出症的临床疗效和影像学变化。方法:回顾性分析248例颈椎间盘突出症患者,124例采用注射胶原酶治疗(A组),同期124例患者采用注射臭氧联合胶原酶治疗(B组)。采用视觉模拟疼痛评分(visual analogue scale,VAS)作为疼痛程度评价指标,改良Macnab标准评估治疗效果。术后6月突出物缩小程度评价影像学改变情况。结果:两组患者术后1天、3天、7天、1个月、3个月、6个月VAS评分较术前均有明显降低(P<0.05),术后臭氧联合胶原酶组较单纯胶原酶组VAS明显降低(P<0.05)。6个月后两组患者优良率分别为82.3%和93.6%,差异具有统计学意义(P<0.05),6个月后两组具有明显影像学改变者分别为83.7%和95.4%,差异具有统计学意义(P<0.05)。结论:CT引导颈后路注射臭氧联合胶原酶髓核溶解术是治疗颈椎间盘突出症有效的方法之一。Objective：To observe the clinical efficacy and the change of image after the treatment of cervical disc hemiation through ligament flava posterior injection of ozone and collagenase under CT.Methods：248 patients,who were diagnosized as cervical disc herniation by MRI or CT,were divided into Group A and B.The injection of collagenase was used in Group A （n =124）.Ozone combined with collagenase was used in Group B （n =124）.Visual analogue scale（VAS） was adopted to assay the degree of pain,improved Macnab criteria was selected to evaluate the clinical efficacy and decreased degree of the protrution size was utilized to evaluate the change of image after 6 months.Results：Compared with pre-operation,VAS scores were decreased significantly from 1st day to 6 months after treatment in two groups （P ＜ 0.05）.Compared with in Goup A,VAS scores were remarkably reduced in Group B after treatment （P ＜ 0.05）.The excellent and good rate was 82.3％ in Group A and 93.6％ in Group B at 6 month after treatment and the differences between them were statistically significant （P ＜ 0.05）.The changed image degree was statistically significant after 6 months in two groups （P ＜ 0.05）.Conclusion：CT-guided injection of ozone and collagenase is an effective procedure for treating cervical disc herniation.

关 键 词：颈椎间盘突出症 臭氧 胶原酶 

分 类 号：R681.53[医药卫生—骨科学]