苦瓜提取物影响Ⅱ型糖尿病小鼠血清SOD、MDA的Meta分析  

Effects of Bitte Mmelon Extract on Serum SOD and MDA in Mice with TypeⅡDiabetes: A Meta- analysis

作　　者：斯琴[1] 布日额[1] 

机构地区：[1]内蒙古民族大学,内蒙古通辽028000

出　　处：《中医药信息》2015年第1期17-20,共4页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(地区科学基金)项目(No.81160552)

摘　　要：目的：系统评价苦瓜提取物对Ⅱ型糖尿病小鼠血清SOD活性、MDA含量的影响.方法：计算机检索中文期刊数据库、维普中文科技期刊数据库、万方数据库收录的1979年1月～2012年12月发表的关于苦瓜提取物影响Ⅱ型糖尿病小鼠血清SOD活性、MDA含量的相关研究,并辅以手工检索,对照纳入标准筛选文献.对符合纳入标准的研究的质量进行评价,采用RevMan5.2软件进行Meta分析.结果：共收集到相关文献23篇,其中符合纳入标准的有6篇7项研究,Meta分析结果显示,小鼠血清SOD活性异质性检测I2 =35％,合并结果Z=5.67（P＜0.00001）;MDA含量异质性检测I2=0％,合并结果Z =6.23（P ＜0.00001）,检验结果均有统计学意义,故采用随机效应模型,合并效应值采用标准化均数差（SMD）,小鼠血清SOD活性的合并效应SMD=-1,15,95％CI（-1.55,-0.75）;MDA含量的合并效应SMD=1.27,95％CI（0.87,1.67）;发表偏倚检测图呈漏斗状.结论：苦瓜提取物能够提高Ⅱ型糖尿病小鼠血清SOD活性,降低MDA含量.Objective ： To systematic review the influence of bitter melon extract on serum SOD activity and MDA in mice with type Ⅱ diabetes. Methods ： The literatures related to effects of bitter melon extract on serum SOD activity and MDA in mice with type Ⅱ diabetes from January 1979 to December 2012 were collected by the computer, aided search of CNKI, VIP and Wan Fang databases combined with manual search. Those qualified studies according to inclusion criteria received quality evaluation and Meta - analysis by RevMan 5.2 software. Resuhs：23 literatures were collected and 7 studies of 6 articles were included among them. Meta -analysis showed Heterogeneity testing of serum SOD activity was 12 = 35 %. The combined result was Z = 5.67 （ P 〈 0. 00001）;heterogeneity testing of MDA was I2 =0%. The combined result was Z =6.23 （P 〈0. 00001 ）. They were statistically significant. Combined effect values of serum SOD activity in mice used the standardized mean differences （ SMD）, SMD = - 1,15,95 % CI （ - 1.55, - 0.75 ） ; combined effect values of MDA in mice used the standardized mean differences （ SMD）, SMD = 1.27,95 % CI （ 0.87,1.67 ） ; publication bias tested graphics funnel. Conclusion ： Bitter melon extract can increase serum SOD activity in mice with type Ⅱ diabe- tes, while decrease MDA in mice with type Ⅱ diabetes.

关 键 词：苦瓜提取物 糖尿病小鼠 SOD MDA META分析 

分 类 号：R285.5[医药卫生—中药学]