加味八珍汤联合小剂量醋酸泼尼松片治疗特发性血小板减少性紫癜临床研究  

Clinical Observation of Jiawei Bazhen Prescription and Small Doses of Western Medicine Prednisone Acetate Tablets for Treating Idiopathic Thrombocytopenic Purpuar

作　　者：文鸿光 文焕琛[2] 

机构地区：[1]深圳市人民医院,广东深圳518033 [2]深圳市中医院,广东深圳518033

出　　处：《中医药信息》2015年第1期82-86,共5页Information on Traditional Chinese Medicine

摘　　要：目的:观察加味八珍汤联合小剂量醋酸泼尼松片治疗特发性血小板减少性紫癜(ITP)的临床疗效。方法:60例符合诊断标准与纳入标准的ITP患者采用区组随机化方法随机分为治疗组(G1)与对照组(G2)。G1组口服中药加味八珍汤与小剂量醋酸泼尼松片;对照组(G2)单纯口服常规剂量醋酸泼尼松片。两组均以6周为1个疗程。连续用药3个疗程后,对比两组间的临床总有效率、血小板计数与中医症状积分的变化情况,并记录G1与G2组不良反应事件的发生状况。结果:1)治疗组的临床总有效率为89.99%,对照组为76.66%,G1、G2组的临床总有效率经组间比较,差异有统计学意义(P<0.05)。2)治疗后,G1组中血小板计数由(39.26±7.32)上升至(112.32±9.28),G2组中血小板计数亦由(40.18±5.36)增加为(95.27±7.45);G1、G2组患者血小板计数经组内、组间比较,差异均具有统计学意义(P<0.05)。3)治疗后,G1组患者的中医症状积分由(34.23±4.52)降至(11.26±2.34),而G2组患者中医症状积分前后变化不明显。G1组患者中医症状积分经组内比较,差异有统计学意义(P<0.05);G2组患者中医症状积分经组内比较,差异无统计学意义(P>0.05)。治疗后,G1与G2组患者中医症状积分经组间比较,差异有统计学意义(P<0.05)。4)G1组中患者出现腹胀2例,不良事件发生率为6.66%;G2组中患者出现肺部感染1例,恶心2例,皮肤瘙痒1例,不良事件发生率为13.33%;两组经组间比较,差异有统计学意义(P<0.05)。结论:加味八珍汤联合小剂量醋酸泼尼松片用于治疗ITP可明显提高患者血小板计数,降低中医症状积分,减少不良反应事件的发生几率,显著提高临床疗效,改善患者的生活质量。Objective：To observe the clinical efficiency of Jiawei Bazhen prescription and small doses of western medicine Prednisone acetate tablets for treating idiopathic thrombocytopenic purpurar. Method：60 patients were randomly divided into a treatment group （ G1 ） and a control group （ G2 ）. Treatment group （ G1 ） was treated with Jiawei Bazhen prescription and small doses of western medicine Prednisone acetate tablets, while control group （G2） was treated by conventional dose of prednisone acetate tablets. After 3 months of treatment com- pare the clinical total effective rate between the two groups, the change of platelet count and the Chinese medi- cine symptom integral, and record the occurrence of adverse events in the G1 and G2 groups. Results ： 1 ） Clin- ically total effective rate was 89.99% in the treatment group, and the control group was 76.66%. The clinical-ly total effective rate of G1, G2 groups by the comparison between groups the difference was statistically signif- icant （P 〈0.05）. 2）After treatment, the platelet count in G1 group from （39.26 ±7.32） to （ 112.32 ±9. 28）, platelet count in the G2 group also increased from （40.18 ±5.36） to （95.27 ±7.45） ; G1 and G2 groups were compared between patients with platelet count by the groups, and the differences were statistically significant （P 〈 0.05 ）. 3 ） After treatment, the G1 group of patients with Chinese medicine symptom integral rating was from （ 34.23 ± 4.52 ） to （ 11.26 ＋_ 2.34）, while G2 group of patients in TCM symptom score before and after the change was not obvious. G1 group of patients with traditional Chinese medicine symptom inte- gral, comparing within the group, the difference was statistically significant （P 〈 0.05） ; G2 group of patients with traditional Chinese medicine symptom integral, comparing within the group, there was no statistically sig- nificant difference （ P 〉 0.05 ）. After treatment, the G1 and G2 groups of patients with Chinese medicine sym

关 键 词：特发性血小板减少性紫癜 加味八珍汤 醋酸泼尼松片 血小板计数 中医症状积分 

分 类 号：R554.6[医药卫生—血液循环系统疾病]