2012年浙江省湖州市自然人群A群C群流脑抗体检测结果及相关性分析  

Detection of antibodies to Neisseria meningitidis serogroup A and C among natural population in Huzhou,Zhejiang and correlation among different indicators,2012

作　　者：沈建勇[1] 罗小福[1] 杨丽萍 邵斌[3] 顾时平[4] 

机构地区：[1]湖州市疾病预防控制中心免疫规划科,浙江湖州313000 [2]南浔区疾病预防控制中心,浙江南浔313000 [3]长兴县疾病预防控制中心,浙江长兴313100 [4]安吉县疾病预防控制中心,浙江安吉313300

出　　处：《疾病监测》2014年第12期944-947,共4页Disease Surveillance

摘　　要：目的了解浙江省湖州市自然人群A群C群流行性脑脊髓膜炎（流脑）抗体水平及相关性,为制定防制策略提供依据。方法采用分层随机抽样方法,分7个年龄组,采集635份健康人群血清,采用酶联免疫吸附试验检测A群、C群流脑Ig G抗体含量,对A群和C群流脑抗体水平进行描述流行病学和相关性分析。结果 A群流脑抗体阳性率和保护率为89.92%和81.89%,C群流脑则为85.20%和63.76%,A群流脑抗体水平总体高于C群。A群流脑各年龄组间阳性率、保护率和抗体含量间存在正相关,7岁以上年龄组C群流脑抗体保护率和含量降幅较阳性率明显,仅保护率和抗体含量间存在正相关。A群、C群流脑抗体各年龄组间同时阳性和同时具有保护水平与C群流脑存在正相关。A群、C群流脑抗体保护率年龄分布均呈单峰分布,其中A群流脑以7～14岁组为最高,C群高峰则在3～4岁组。5岁以下人群A群、C群流脑抗体阳性率、保护率、抗体含量差异无统计学意义,且抗体保护水平定性检测结果存在一致性。结论湖州市存在C群流脑流行的血清学基础,需进一步加强含C群流脑成分疫苗接种。建议使用A群C群流脑结合疫苗代替2岁以内接种的A群流脑多糖疫苗,并对2岁以上儿童直接使用A群C群流脑多糖疫苗进行接种。Objective To understand antibody level to Neisseria meningitidis serogroups A and C among natural population in Huzhou, Zhejiang province and the correlation among different indicators, and provide scientific evidence for the prevention and control of meningococcal meningitis. Methods The serum samples were collected from 635 local healthy subjects selected in 7 age groups through stratified random sampling to conduct the detection of antibodies （IgG） to N. meningitidis serogroup A and C with enzyme-linked immunosorbent assay （ ELISA）, and the antibody level and related indciators＇correlation were analyzed in different groups. Results The positive rate and protective rate of IgG to N. meningitidis serogroup A were 89. 92% and 81.89% and the positive rate and protective rate of IgG to serogroup C were 85.20% and 63.76%. The positive correlation was observed among the positive rate, protective rate and antibody level of serogroup A in all age groups. To serogroup C, more decline in protective rate and antibody level were observed than in positive rate in age group 〉 7 years, only the protective rate was positively correlated with the antibody level. The highest protective rate of serogroup A was in age group 7 - 14 years, while the highest protective rate of serogroup C was in age group 3 -4 years. No significant difference in antibody protective rate, protective rate and antibody level were observed between serogroup A and serogroup C in age group 〈 5 years. Conclusion The protective rate of IgG to N. meningitidis serogroup A was high among the natural population in Huzhou. It is necessary to replace serogroups A meningococcal polysaccharide vaccine used in age group 〈 2 years with serogroup A and C meningococcal conjugate vaccine, and serogroups A and C meningococcal conjugate polysaccharide vaccine could be used in age group 〉 2 years.

关 键 词：流行性脑脊髓膜炎 疫苗 抗体水平 相关性 

分 类 号：R515.2[医药卫生—内科学]