血栓弹力图法与光学比浊法监测氯吡格雷疗效的对比研究  

Comparatively Study on the Thromboelastography and Light Transmission Aggregometry in Monitoring Clopidogrel Effect

作　　者：黄媛[1] 张伟[1] 杨倩琳[1] 张婷[1] 谢之华[1] 

机构地区：[1]军事医学科学院附属医院检验科,北京100071

出　　处：《现代检验医学杂志》2014年第6期113-115,共3页Journal of Modern Laboratory Medicine

摘　　要：目的：对比研究监测急性冠状动脉综合征患者氯吡格雷疗效的两种方法：血栓弹力图法（TEG）与光学比浊法（LTA）。方法用 LTA法与TEG法检测2013年2月～12月期间心内科68例急性冠状动脉综合征患者的血小板聚集功能，并对两种方法的检测结果进行比较。结果 TEG监测的血小板抑制率为（47.84±26.04）％，LTA监测的血小板聚集率为（45.64±20.92）％。患者组中 LTAADP与TEGADP存在负相关（r＝－0.752，P＜0.001）；LTAADP与 MAADP存在正相关（r＝0.789，P＜0.001）；TEGADP与 MAADP呈负相关（r＝－0.820，P＜0.001）。结论 TEG血小板图与 LTA监测氯吡格雷疗效具有较好的相关性。用 MAADP联合TEGADP监测氯吡格雷抗血小板治疗效果，可提供更高的临床预测价值。Objective To comparatively study the difference between thromboelastography （TEG）and light transmission ag-gregometry （LTA）in monitoring clopidogrel effect in patients with acute coronary syndrome.Methods 68 patients with a-cute coronary syndrome,who were in hospital from February to December 2013,were enrolled in this study.They received TEG and LTA to determine platelet aggregation.Results Clopidogrel effect was （47.84±26.04）% and （45.64±20.92）%respectively by TEG and LTA.There were negative correlation between LTAADP and TEGADP（r=-0.752,P〈0.001）,pos-itive correlation between LTAADP and MAADP（r=0.789,P〈0.001）,negative correlation between TEGADP and MAADP（r=-0.820,P〈0.001）.Conclusion There was a good correlation between the two methods.TEG can be used to evaluate thera-peutic effect of Clopidogrel effect.

关 键 词：急性冠状动脉综合征 氯吡咯雷 光学比浊法 血栓弹力图 

分 类 号：R543.3[医药卫生—心血管疾病] R446.111[医药卫生—内科学]