糖尿病患者血清同型半胱氨酸、脂蛋白a、超敏C反应蛋白联合检测的临床意义  

Clinical Significance of Detecting the Levels of Homocysteine, Combined with Lipoprotein（a）and High Sensitivity C-reaction Protein in Serum from Patients with Diabetes Mellitus

作　　者：李琳 涂欢 朱武[3] 陈卫红 王华[5] 沈建军[6] 

机构地区：[1]安康市中医院内三科,陕西安康725000 [2]安康市中医院糖尿病免疫科,陕西安康725000 [3]安康市中医院检验科,陕西安康725000 [4]安康市中医院肾病科,陕西安康725000 [5]安康市中医院眼科,陕西安康725000 [6]第四军医大学唐都医院临床实验与检验科,西安710038

出　　处：《现代检验医学杂志》2014年第6期148-149,152,共3页Journal of Modern Laboratory Medicine

摘　　要：目的：探讨联合检测糖尿病患者血清同型半胱氨酸（Hcy）、脂蛋白 a[Lp（a）]、超敏 C反应蛋白（hsCRP）水平的临床意义。方法检测30例糖尿病并发微血管病变患者、30例单纯糖尿病患者、44例健康体检者的血清 Hcy，Lp（a）和hsCRP水平，用 SPSS13.0统计学软件处理数据。结果糖尿病并发微血管病变组血清 Hcy，Lp（a）和 hsCRP水平均显著高于单纯糖尿病组和健康对照组（P＜0.05），单独检测时，Lp（a）的阳性率高于 Hcy和 hsCRP 的阳性率，Hcy，Lp（a）和hsCRP联合检测时，阳性率高于各个项目单独检测的阳性率。结论 Hcy，Lp（a）和 hsCRP与糖尿病微血管病变的发生、发展关系密切，三者联合检测对监测糖尿病微血管病变的发生、发展具有一定的临床应用价值。Objective To study the clinical significance of detecting the levels of homocysteine,lipoprotein（a）and high sensi-tivity C-reaction protein in serum from patients with diabetes mellitus.Methods Serum Hcy,Lp（a）and hsCRP levels were detected from 30 patients of diabetes mellitus with microangiopathy,and 30 patients of simple diabetic,45 heslthy individuals as normal controls,all the data were analysed by SPSS13.0 software.Results The levels of Hcy,Lp（a）and hsCRP in dia-betes mellitus with microangiopathy group were higher than that of normal controls and simple diabetic group.In all groups, the positive rate of Lp（a）was highest （P〈0.05）.Detecting the serun Hcy combined with Lp（a）and hsCRP had higher positive rate then single detecting （P〈0.05）.Conclusion The generation and development of diabetes mellitus were corre-lated with the serum levels of Hcy,Lp（a）and hsCRP.Detecting the serum Hcy combined with Lp（a）and hsCRP have more clinical significance than single detecting.Serum Hcy,Lp（a）and hsCRP level has the remarkable significance to diagnosis and prediction diabetes mellitus with microangiopathy.

关 键 词：糖尿病 同型半胱氨酸 脂蛋白A 超敏C反应蛋白 

分 类 号：R587.1[医药卫生—内分泌] R446.112[医药卫生—内科学]