血清脂联素、瘦素、白介素-18的变化在初发2型糖尿病患者中的意义  

The clinical significance of the changes of serum adiponectin,leptin,and interleukin-18 in patients with incipient type 2 diabetes

作　　者：徐欢[1] 胡欣[1] 温玉洁[1] 郝丽莉[1] 董昀[1] 

机构地区：[1]广西壮族自治区南溪山医院内分泌科,广西桂林541002

出　　处：《华夏医学》2014年第6期45-48,共4页Acta Medicinae Sinica

基　　金：广西壮族自治区卫生厅自筹经费科研课题(Z2011024)

摘　　要：目的:研究初发2型糖尿病(T2DM)患者血清脂联素(APN)、瘦素(LP)、白介素-18(IL-18)的变化与糖脂代谢的关系。方法:检测并比较正常体重(A组,10例)及超重(B组,10例)非糖尿病自愿者,正常体重(C组,32例)及超重(D组,35例)2型糖尿病患者的体重指数(BMI)、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR),APN、IL-18及LP。结果:B组及D组LP、IL-18高于A组及C组(P<0.05),且C组IL-18高于B组(P<0.05),APN在A、B、C、D 4组中逐渐下降,组间比较,差异有统计学意义(P<0.05),IL-18与BMI、HOMA-IR正相关,与APN负相关(P<0.05);APN与BMI、LP、HOMA-IR负相关(P<0.05);LP与BMI正相关(P<0.05)。结论:低APN和高IL-18血症可能是糖尿病的危险因素,其代谢紊乱与胰岛素抵抗密切相关,而LP可能只与肥胖相关。Objective： To investigate the correlation between levels of adiponectin （APN）, leptin （LP）, change of interleukin-18 （IL-18） of TzDM patients and the glucose metabolism. Methods： 10 non-diabetic cases with （Group A）, 10 non-diabetic cases with normal weight overweight （Group B）, 32 cases of type 2 diabetes mellitus with normal we betes mellitus with over weight （Group D） were include lg d ht （Group C）, and 35 cases of type 2 dia- in the study respectively. The correlation of BMI, adiponectin, IL-18, fasting plasma glucose （FPG）, fasting insulin （FINS）, insulin resist- ance of homeostasis model assessment （HOMA-IR）, APN, IL-18 and LP were detected among all patients respectively. Results： LP and IL-18 levels in Group B and D were significantly higher than those in Group A and C respectively （P〈0.05）, IL-18 levels in C group was also higher than that in B group, and APN levels gradually decreasedin four groups （P〈0. 05）. Correlation analysis showed that IL-18 was positively correlated with BMI, HOMA-IR, but negatively correlated with APN （P〈0.05）, and APN was negatively LP was positively correlated with BMI in Low APN and high IL-18, LP may be one ic disorders are closely related with insulin correlated with BMI, LP, HOMA-IR （P〈0.05）, while patients with type 2 diabetes （P〈0.05）. Conclusion： of the factor in pathogenesis of diabetes, whose metabol resistance.

关 键 词：2型糖尿病 脂联素 瘦素 白介素-18 

分 类 号：R587.1[医药卫生—内分泌]