血清中EmAb、AsAb、UU及CT水平与女性不孕不育的关系  

The relationship of the levels of Em Ab,As Ab,UU and CT of serum and cervical mucusand with female infertility

作　　者：陆小建[1] 

机构地区：[1]江苏省如皋市中医院检验科,江苏南通226500

出　　处：《中国优生与遗传杂志》2014年第12期114-115,75,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨血清中抗子宫内膜抗体(Em Ab)、抗精子抗体(As Ab)、解脲支原体(UU)及沙眼衣原体(CT)水平与女性不孕不育的关系及其临床应用价值。方法 2011年6月至2014年5月采用酶联免疫法测定120例不孕不育患者及120例健康女性体检者(对照组)血液Em Ab、As Ab蛋白表达水平,应用胶体金方法测定两组血清中UU及CT水平。结果不孕不育组血清中Em Ab、As Ab、UU、CT阳性率分别为81.67%、76.67%、68.33%、70.83%高于对照组6.67%、4.17%、10.00%、6.67%,与单一检测相比,血清及宫颈粘液中Em Ab、As Ab、UU及CT联合检测的准确性、灵敏性、阳性预测值、阴性预测值较高,差异有统计学意义(P<0.05)。结论 Em Ab、As Ab、UU及CT水平与女性不孕不育具有密切的关系,可作为女性不孕不育的常规检查项目。通过联合检测的方法可提高诊断灵敏性及特异性。Objective： To investigate the levels of serum endometrial antibody （EmAb） , anti-sperm antibodies （AsAb） , voiding mycoplasma （UU） and Chlamydia trachomatis （CT） of Female infertility and its clinical application value. Methods： The levels of EmAb, AsAb protein of lood and cervical fluid polymerase and the levels of UU and CT of 120 cases of infertility patients and 120 healthy female volunteers （control group） were determined by ELISA and measured with polymerase chain reaction （PCR） from June 2012 to June 2014. Results： The positive rates of EmAb, AsAb, UU, CT of serum （81.67%, 76.67%, 68.33%, 70.83%） of were higher than control group （6.67%, 4.17%, 10.00%, 6.67） . The sensitivity, positive predictive value, negative predictive value of EmAb, AsAb, UU and CT combined detection of serum and cervical mucus were higer than single detection （P〈0.05） . Conclusion： EmAb, AsAb, UU and CT levels and female infertility have a close relationship, as female infertility routine examination. Through joint detection method can improve the diagnostic sensitivity and specificity.

关 键 词：血清 抗子宫内膜抗体 抗精子抗体 解脲支原体 沙眼衣原体 

分 类 号：R711.6[医药卫生—妇产科学]