阿托伐他汀治疗心肌梗死疗效Meta分析  

Meta-analysis of curative effects of atorvastatin on myocardial infarction

作　　者：金永彪[1] 车成日[1] 金虎日[1] 林星[1] 白金权[1] 张恒飞[1] 姜云峰[1] 

机构地区：[1]延边大学附属医院胸外科,吉林延吉133000

出　　处：《延边大学医学学报》2014年第4期291-294,共4页Journal of Medical Science Yanbian University

摘　　要：[目的]评价阿托伐他汀治疗心肌梗死的效果及安全性.[方法]计算机检索Cochrane图书馆临床对照试验资料库、Pubmed、中国知网、万方数据库及重庆维普中文科技期刊全文数据库,手工检索药物及心血管相关期刊及会议报告,纳入阿托伐他汀治疗心肌梗死效果的随机对照试验,经质量评估、数据提取对符合标准的随机对照试验进行Meta分析.[结果]共纳入9个随机对照试验,共计789例心肌梗死患者.Meta分析结果显示,与对照组比较,实验组心肌梗死患者给予阿托伐他汀治疗后总胆固醇(TC)水平明显降低(MD=0.97,95%CI:0.85~1.09,P<0.000 01);三酰甘油(TG)水平明显降低(MD=0.75,95%CI:0.67~0.83,P<0.000 01);低密度脂蛋白胆固醇(LDL-C)水平明显降低(MD=0.24,95%CI:0.17~0.31,P<0.000 01);高密度脂蛋白胆固醇(HDL-C)水平明显升高(MD=-0.30,95%CI:-0.37^-0.24,P<0.000 01).[结论]阿托伐他汀可有效治疗心肌梗死,明显降低心肌梗死患者的TC,TG,LDL-C水平,明显升高HDL-C;因文献质量较低,影响了结果的准确性,仍需要质量较高的随机对照试验来进行评价.OBJECTIVE To evaluate the curative effects and safety of atorvastatin on myocardial infarction（MI）.METHODS The databases of Cochrane Library,Embass,PubMed,CNKI,VIP,Wang Fang Database were retrieved for collecting the randomized controlled trials（RCT）and before after auto-controlled studies,reference literature and relative journals and meeting reports were retrieved manually.After quality assessments and data extractions,all RCT accorded with standard were given a Meta-analysis.RESULTS There were total 9RCT and 789 cases of MI in this analysis.The results of Meta-analysis showed that the TC（MD=0.97,95%CI：0.85~1.09,P〈0.000 01）,TG（MD=0.75,95%CI：0.67~0.83,P〈0.000 01）and LDL-C（MD=0.24,95%CI：0.17~0.31,P〈0.000 01）decreased significantly and HDL-C（MD=-0.30,95%CI：-0.37^-0.24,P〈0.000 01）increased significantly in MI patients after treatment with atorvastatin as compared with control group.CONCLUSION Atorvastatin treats effectively the MI,and is decrease of TC,TG and LDL-C and increase of HDL-C in MI patients.,The accuracy of results are affected because of low literature quality,and it is still needed to evaluate with high quality RCT.

关 键 词：心肌梗死 阿托伐他汀 随机对照试验 META分析 

分 类 号：R542.2[医药卫生—心血管疾病]