父婴乙型肝炎传播情况及乙型肝炎疫苗联合乙型肝炎免疫球蛋白阻断父婴乙型肝炎传播的效果观察  

Observation on status of father to infant transmission of hepatitis B and effects of blocking father to infant hepatitis B transmission by hepatitis B vaccine combined with hepatitis B immunoglobulin

作　　者：太永日[1] 吴春华[1] 

机构地区：[1]延边大学附属医院,吉林延吉133000

出　　处：《延边大学医学学报》2014年第4期301-302,共2页Journal of Medical Science Yanbian University

摘　　要：[背景]调查父婴乙型肝炎传播情况,观察乙型肝炎疫苗联合乙型肝炎免疫球蛋白阻断父婴乙型肝炎传播的效果.[病例报告]采用随机化方法选择父亲HbsAg阳性和母亲HbsAg阴性婴幼儿作为研究对象,分为观察组和对照组,观察组婴幼儿给予乙型肝炎疫苗联合乙型肝炎免疫球蛋白,对照组只进行乙型肝炎疫苗常规接种,观察2组婴幼儿HbsAg阳性率.父亲HbsAg阳性及母亲HbsAg阴性组父婴乙型肝炎传播率(8.2%)明显高于父亲及母亲HbsAg阴性组(0.8%,P<0.01);观察组HbsAg阳性率(1.0%)明显低于对照组(7.0%,P<0.05).[讨论]HBsAg阳性父亲是乙型肝炎家族传播的传染源.乙型肝炎疫苗联合乙型肝炎免疫球蛋白阻断父婴乙型肝炎传播是阻断乙型肝炎蔓延的有效措施,在临床上值得推广应用.BACKGROUND To investigate the status of father to infant transmission of hepatitis B and to observe the effects of blocking father to infant hepatitis B transmission by hepatitis B vaccine combined with hepatitis B immunoglobulin.CASE REPORTS Infants with HbsAg-positive fathers and HbsAg-negative mothers were selected by randomized method,and divided into observation and control groups.The infants in observation group were administrated by hepatitis B vaccine combined with hepatitis B immune globulin,and in control group by only routine immunization hepatitis B vaccine,and HbsAg-positive rate was observed in two groups.The father to infant transmission rate（8.2%）of hepatitis B in group with HbsAg-positive fathers and HbsAg-negative mothers was significantly higher than that in group with in HbsAg-negative parents（0.8%,P〈0.01）,and HbsAg-positive（1.0%）in observation group was significantly lower than that in control group（7.0%,P 0.05）.DISCUSSION HBsAg-positive father is source of infection in familial transmission of hepatitis B,and the blocking father to infant hepatitis B transmission by hepatitis B vaccine combined with hepatitis B immunoglobulin is is an effective measure to block the spread of hepatitis B,and it should be used as a preventive measures in clinical practice.

关 键 词：乙型肝炎疫苗 乙型肝炎免疫球蛋白 乙型肝炎病毒 父婴传播 

分 类 号：R512.62[医药卫生—内科学]